Familial Clustering of Vitamin D Deficiency Via Shared Environment: The Korean National Health And Nutrition Examination Survey 2008-2012

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03349879

Enrollment

28551

Registered

2017-11-22

Start date

2008-01-01

Completion date

2012-12-31

Last updated

2017-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Vitamin D Deficiency

Brief summary

Vitamin D deficiency is a modifiable risk factor for poor bone health. Familial correlation of serum 25-hydroxyvitamin D concentration (25(OH)D) was reported in twin- or family-based studies, mostly from Caucasian parent-offspring pairs. However, data on the familial association of 25(OH)D in extended family structure and the relative contribution of genetic and shared environmental factors on serum 25(OH)D level are limited in Asian populations. In this study, the investigators aimed to assess the relative contribution of additive genetic and environmental components on serum 25(OH)D level by variance components method in a nationwide family-based cohort. Further, the investigators will evaluate the association of vitamin D status of index individual with prevalent vitamin D deficiency of each family member including spouse, offspring, sibling, and grand-offspring. Additive influences of paternal and maternal vitamin D status on offspring will be also investigated.

Detailed description

From the Korean National Health and Nutritional Examination Survey (KNHANES) conducted between 2008 and 2012, familial correlations for 25(OH)D will be estimated in different types of family relation pairs in 28551 subjects from 10882 families. The relative contribution of additive genetic and shared or individual environmental factors for variance of 25(OH)D level will be calculated using variance component method. Interactions between paternal and maternal vitamin D status for 25(OH)D level of offspring will be evaluated.

Interventions

None listed

Study design

Observational model

FAMILY_BASED

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

10 Years to 95 Years

Healthy volunteers

Yes

Inclusion criteria

* KNHANES(Korean National Health and Nutrition Examination Survey) 2008-2012 participants

Exclusion criteria

* missing value on 25-hydroxyvitamin D levels * data on another household member was unavailable * the precise family relationship between the subjects was unclear

Design outcomes

Primary

Measure	Time frame	Description
Vitamin D deficiency	1 minute after the survey (cross-sectional analysis)	Vitamin D deficiency (serum 25(OH)D \< 30 nmol/L)

Countries

South Korea

Outcome results