Fish and Marine Fatty Acids, Genetic Signatures of Diet Adaptation, and Long-term Weight Changes

Fish and Marine Fatty Acids, Genetic Signatures of Diet Adaptation, and Long-term Weight Change

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03348566

Enrollment

22000

Registered

2017-11-21

Start date

2015-02-01

Completion date

2016-03-01

Last updated

2023-12-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity

Brief summary

the investigators tested whether genetic variants near FADS cluster, which were recently identified to be signatures of adaptation to fish- and n-3 PUFAs-rich diet, interacted with these dietary factors on long-term change of body mass index (BMI).

Interventions

OTHERfish

fish intkae

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* 11,323 women of European ancestry. * Informed consent was obtained from all participants. The DNA extraction methods, quality control measures, * SNPs genotyping and imputation data are available . * Both cases and controls with genotyping data are available based on GWASs

Exclusion criteria

* participants without genetic data

Design outcomes

Primary

Measure	Time frame	Description
weight changes	6-10 years	long term weight changes: this study measured body weight at baseline (1990) and follow up body weight in 2000. The long term body weight was defined as changes from baseline to follow up endpoint

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026