Congenital Heart Defect, Right Ventricular Outflow Tract Reconstruction
Conditions
Brief summary
Pulmonary homografts are standard substitutes for right ventricular outflow tract reconstruction in congenital heart surgery. Unfortunately shortage and conduit failure secondary to early calcifications and shrinking are observed particularly for small sized conduits in younger patients. In neonates, Contegra® 12mm could be a valuable alternative, but conflicting evidence exists. This retrospective study compared the outcome of these two conduits in a newborn population.
Interventions
PROCEDUREright ventricular outflow tract reconstruction with contegra
Contegra pulmonary valved conduit is an animal jugular vein that contains a valve with three leaflets that are similar to a human heart valve.
PROCEDUREright ventricular outflow tract reconstruction with pulmonary homograft
cryopreserved pulmonary homografts
Sponsors
Queen Fabiola Children's University Hospital
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
No minimum to 30 Days
Healthy volunteers
No
Inclusion criteria
neonatal patients who had a reconstruction of the right ventricular outflow tract with a pulmonary homograft or a Contegra between January 1992 and December 2014 at HUDERF
Exclusion criteria
NA
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comparison of mid term course between pediatric right ventricular outflow tract recontruction with homograft and contegra | up to 195 months post right ventricular outflow tract recontruction |
Secondary
| Measure | Time frame |
|---|---|
| Proportion of early conduit-related reintervention according to the congenital heart defect diagnosis | up to 195 months post right ventricular outflow tract recontruction |
| Proportion of early conduit-related reintervention in right ventricular outflow tract recontructed with contegra | up to 195 months post right ventricular outflow tract recontruction |
| Proportion of early conduit-related reintervention in right ventricular outflow tract recontructed with pulmonary homograft | up to 195 months post right ventricular outflow tract recontruction |
| Proportion of early conduit-related reintervention according to the Nakata index | up to 195 months post right ventricular outflow tract recontruction |
| Overal mortality in right ventricular outflow tract recontructed with pulmonary homograft | up to 195 months post right ventricular outflow tract recontruction |
| Residual pulmonary arterial hypertension rate in right ventricular outflow tract recontructed with contegra | up to 195 months post right ventricular outflow tract recontruction |
| Residual pulmonary arterial hypertension rate in right ventricular outflow tract recontructed with pulmonary homograft | up to 195 months post right ventricular outflow tract recontruction |
| Overal mortality in right ventricular outflow tract recontructed with contegra | up to 195 months post right ventricular outflow tract recontruction |
Countries
Belgium
Outcome results
None listed