Cocaine Use Disorder
Conditions
Brief summary
The goal of this study is to compared \[C-11\]NOP-1A binding in recently abstinent cocaine use disorders and controls.
Detailed description
This will allow for understanding brain stress and anti-stress mechanisms that underlie abuse of cocaine in humans.
Sponsors
National Institute on Drug Abuse (NIDA)
University of Pittsburgh
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Intervention model description
\[C-11\]NOP-1A
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
\[A\]Cocaine use disorders Inclusion criteria: 1. Males or Females 18-50 2. Fulfill DSM-5 Diagnosis for Cocaine use disorder 3. Medically Healthy Major
Exclusion criteria
1. Pregnancy or lactation 2. Comorbid medical, psychiatric, drug use disorders (other than cocaine, tobacco use, and recreational marijuana/alcohol use) 3. Metal implants or paramagnetic objects contained within the body which may interfere with the MRI scan 4. Currently employed as radiation worker; or participation in radioactive drug research protocols within the previous year 5. Currently on any psychotropic medications that can influence nociceptin transmission in the brain (e.g., morphine, suboxone, SSRIs, etc.) \[B\] Healthy controls Inclusion criteria: 1. Males or Females 18-50 2. Absence of present or past psychiatric conditions (including alcohol or drug use disorders) 3. A negative urine drug screen 4. Medically Healthy Major
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| [C-11]NOP-1A VT | Baseline | VT-volume of distribution expressed relative to total plasma |
Countries
United States
Outcome results
None listed