The Effects of Ethanol on Intestinal Permeability and Gut Hormones

The Effects of Orally Ethanol vs. Isoethanolaemic i.v. Infusion of Ethanol on Intestinal Permeability and Gut Hormones

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03348371

Enrollment

Registered

2017-11-20

Start date

2016-08-01

Completion date

2017-10-01

Last updated

2017-11-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ethanol, Incretin Effect, Insulin Resistance

Keywords

Incretin effect, Ethanol

Brief summary

The aime of this study is to envsitigate if ethanol has an incretin effect. This is done by administration of ethanol orally vs. an isoethanolaemic i.v. infusion of ethanol.

Interventions

OTHEREthanol

The intervention is two different administrationforms of ethanol, orally and i.v.

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

MALE

Age

20 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

* Caucasian male between 20 and 50 years of age * Body mass index (BMI) between 19 and 25 kg/m2 * Weekly alcohol intake of less than 14 units of alcohol (of 12 g) * Normal fasting plasma glucose concentration (i.e. \<6 mmol/l) and normal glycated haemoglobin A1c (HbA1c) (i.e. ≤42 mmol/mol) * Normal haemoglobin * Informed consent

Exclusion criteria

* First-degree relatives with diabetes and/or liver disease * Liver disease or other alcohol-related diseases, diabetes mellitus * Liver disease (serum ALAT and/or serum ASAT \>2 × normal values) * Nephropathy (serum creatinine above normal range and/or albuminuria)

Design outcomes

Primary

Measure	Time frame	Description
Serum insulin level	2 month	difference in serum insulin level between the two administration forms

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026