Gabapentin Oral Solution in Decreasing Desflurane Associated Emergence Agitation

The Role of Gabapentin Oral Solution in Decreasing Desflurane Associated Emergence Agitation and Delirium in Children After Strabismus Surgery: A Prospective Randomized Double-blind Study

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03347916

Enrollment

Registered

2017-11-20

Start date

2017-01-05

Completion date

2017-11-30

Last updated

2017-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Emergence Agitation After Desflurane Anesthesia

Brief summary

to study the effect of oral gabapentin (5 mg/kg) on emergence agitation after desflurane anesthesia in pediatrics undergoing starbismus surgery

Interventions

DRUGStrawberry juice as (placebo)

Patients received strawberry juice 5 ml volume, one hour before induction.

DRUGGabapentin Oral Solution [Neurontin]

Patients received gabapentin (Neurontin oral solution 250 mg/ml, Pfizer, USA) 5 mg/kg mixed with strawberry juice to constitute 5 ml volume, one hour before induction.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Caregiver, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

2 Years to 6 Years

Healthy volunteers

Inclusion criteria

* pediatric patients (2-6 years old), with an American society of Anesthegiologists physical status (ASA) I-II who were undergoing strabismus surgery (for more than one muscle)

Exclusion criteria

* failure to obtain consent, mental retardation or developmental delay, epilepsy, psychiatric or neurological diseases that impair communication, current use of gabapentin, psychotropic or opioids.

Design outcomes

Primary

Measure	Time frame	Description
emergence agitation incidence and scores	through study completion, an average of 1 year	agitation measured by emergence agitation scale: \[1= Obtunded with no response to stimuli; 2= Asleep, but responsive to movement and stimuli; 3= Awake and appropriately responsive; and 4= Crying and difficult to console; 5= Wild thrashing behaviour that requires restraint\]. A score 4 or 5 was considered as agitation and was treated by IV meperidine 0.5 -1 mg/kg increments.

Secondary

Measure	Time frame	Description
duration of emergence	through study completion, an average of 1 year	The time from the discontinuation of anesthesia till the time of spontaneous eye opening or to verbal command

Countries

Kuwait

Contacts

Primary ContactAhmed A. BAdawy, MD

dr.ahmedbadawy545@gmail.com+96597700293

Backup ContactNicolas Abou Chaar, MsSc

nicolas.abouchaar@gmail.com+96597714558

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 24, 2026