Prevalence and Clinical Characteristics of Patients With Jackhammer Esophagus and Symptoms of Gastroesophageal Reflux Disease

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03347903

Enrollment

Registered

2017-11-20

Start date

2014-01-01

Completion date

2017-05-30

Last updated

2017-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Esophageal Motility Disorders

Keywords

esophagus, motility

Brief summary

Gastroesophageal reflux disease (GERD) is involved in the development of esophageal motility disorders like Jackhammer esophagus (JE), a novel hypercontractile condition that was associated with progression to achalasia and limited outcomes following surgical anti-reflux therapy. This trial was designed to assess the prevalence and characteristics of JE in patients with typical symptoms of GERD and responsiveness to PPI therapy.

Detailed description

Jackhammer esophagus is a novel hypercontractile esophageal disorder. The investigators assess the prevalence and clinical characteristics of patients diagnosed with this disorder out of a collective of patients that are referred with symptoms of gastroesphageal reflux disease and respond to PPI. This is an observational trial.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Inclusion criteria

* Patients with symptoms of gastroesophageal reflux disease and diagnosis of Jackhammer esophagus

Exclusion criteria

* patients not willing to participate data or undergo screening for gastroesophageal reflux disease

Design outcomes

Primary

Measure	Time frame	Description
Prevalence of Jackhammer esophagus in patients referred with symptoms of gastroesophageal reflux disease	January 2014- May 2017	All patients that are referred to our center with symptoms of gastroesophageal reflux disease routinely undergo high-resolution manometry. We assess how many patients are diagnosed with Jackhammer esophagus

Secondary

Measure	Time frame	Description
Symptom perception	January 2014- May 2017	We assess which symptoms are perceived by the patients diagnosed with Jackhammer esophagus. All data are observed during an interview at the high-resolution manometry
Prevalence of gastroesophageal reflux disease in patients with Jackhammer esophagus	Januar 2014- May 2017	All patients that are referred to our center are evaluated for gastroesophageal reflux disease. We assess the prevalence of gastroesophageal reflux disease in patients with Jackhammer esophagus diagnosed by ambulatory pH monitoring.

Outcome results