Brain Function in Adolescent Eating Disorders and Healthy Peers

Neurocircuitry of Temperament and Motivated Behavior in Adolescent Eating Disorders

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03347565

Enrollment

155

Registered

2017-11-20

Start date

2017-07-21

Completion date

2026-05-08

Last updated

2026-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Eating Disorder

Keywords

adolescents, healthy controls

Brief summary

This study of adolescent eating disorders (ED) will examine the association of temperament-based classifications, brain activation during incentive processing, and ED symptoms at time of scan and 1 year later to better understand the neurobiology and symptoms of ED. We will recruit 150 females currently ill with an ED and 50 controls ages 14-17 to investigate how temperaments reflecting greater inhibition, impulsivity, or effortful control correspond to 1) clinical symptoms and 2) the brain's response to anticipation and outcome of salient stimuli, and 3) by collecting follow-up clinical data one year later, identify how temperament-based subtypes predict ED symptom change (e.g., clinical prediction). Data collection will rely on a technology called functional magnetic resonance imaging (fMRI).

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

14 Years to 17 Years

Healthy volunteers

Yes

Inclusion criteria

* Female * Meet DSM-V criteria for an Eating Disorder or Never met criteria for an Eating disorder * Medically stable * Post-Pubertal (must have started menses, but subsequent loss of menses secondary to ED is fine).

Exclusion criteria

* Psychotic illness/other mental illness requiring hospitalization * Current dependence on drugs or alcohol * Physical conditions known to influence eating or weight (e.g, diabetes mellitus, pregnancy). * On psychoactive medication * Organic brain syndromes, delirium, psychotic disorders, or intellectual disability * Neurological or medical disorders such as seizure disorder * Any contraindication to undergoing an MRI * Major depressive disorder * Left handed

Design outcomes

Primary

Measure	Time frame	Description
Brain function	1 year (fMRI Scan)	Functional Magnetic Resonance imaging will be used to assess brain activation associated with inhibition, impulsivity, and control

Countries

United States

Outcome results