Solid Tumors
Conditions
Brief summary
The main purpose of this study is to define the molecular profile of selected solid tumors. From each participants will be collected biological materials for molecular analysis, including saliva, blood and vital tumor tissue derived form surgical or biopsy procedures. Whereas possible, vital tumor specimens will be inoculated and propagated in immunocompromised NOD/SCID mice to study the genetic correlations between genetic status and response to target drugs.
Interventions
None listed
Sponsors
Fondazione del Piemonte per l'Oncologia
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Patients with at least one of the following selected solid tumors: * Colorectal Cancer (primary or with synchronous/metachronous liver metastases) * Prostate Cancer * Head \& Neck Tumors * Gastric Cancer * Glioblastoma * Breast Cancer * Hepatocarcinoma * Biliary Tract Carcinoma * Lung Cancer (primary) * Rare Tumors (incidence ≤ 5x10-6) * Metastatic Sarcoma * Metastatic Melanoma
Exclusion criteria
\-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| number of patient correctly sampled | through study completion, an average of five years | number of patients with biological samples idoneous for molecular profiling testing (nucleic acid extraction, protein) over all recruited patients. |
Secondary
| Measure | Time frame |
|---|---|
| number of patients with detected genetic alterations that respond to treatments assigned by physician. | through study completion, an average of five years |
Countries
Italy
Outcome results
None listed