Renal Failure
Conditions
Keywords
Energy expenditure, Peritoneal dialysis
Brief summary
The daily energy expenditure of patients treated with peritoneal dialysis could be increased compared to the general population and promote the development of a state of undernutrition. Conversely, the absorption of glucose by transperitoneal route could contribute to the occurrence of a metabolic syndrome. The main objective is to compare DE and its variations according to the conditions (rest, sleep, meals, physical activity) in patients treated with automated DP compared to controls, in a calorimetric chamber.
Detailed description
The daily energy expenditure of patients treated with peritoneal dialysis could be increased compared to the general population and promote the development of a state of undernutrition. Conversely, the absorption of glucose by transperitoneal route could contribute to the occurrence of a metabolic syndrome. The main objective is to compare DE and its variations according to the conditions (rest, sleep, meals, physical activity) in patients treated with automated DP compared to controls, in a calorimetric chamber.
Interventions
BEHAVIORALautomated DP
Energy expenditure measurement
BEHAVIORALCalorimetric chamber
The main objective is to compare DE and its variations according to the conditions (rest, sleep, meals, physical activity) in patients treated with automated DP compared to controls, in a calorimetric chamber
Sponsors
Pôle Santé République
Service de Néphrologie et Hémodialyse
Jacques Lacarin Hospital Center
University Hospital, Clermont-Ferrand
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Masking description
No masking
Eligibility
Sex/Gender
MALE
Age
18 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* Patients Group DPA * Male patients * Aged 18 to 70 years * With end-stage renal disease * Treated by automatic peritoneal * Social security cover * Without acute events in the 3 months prior to inclusion * PCR \< 30 mg/L * Written informed consent * Baecke activity score from 5 to 10 Healthy Volunteers * Male patients * Aged 18 to 70 years * Patients matched by lean body mass (± 2 kgs) and age (± 5 years) * Having a glomerular filtration rate estimated with the formula CKD-EPI creatinine \> 60 mL / min / 1.73 m 2 * PCR \< 3 mg/L * Social security cover * Written informed consent * Baecke activity score from 5 to 10
Exclusion criteria
* • - Female * Type 1 or 2 diabetes requiring a antidiabetic treatment * Decompensated heart failure * Smoking more than 5 cigarettes a day * Alcoholic patients, drinking more than 3 glass of alcohol a day * Patient Corticotherapy in progress * Patient with evolutive acute pathology * Person who has participated in another study within the last 30 days or is in period of exclusion on the National File of Healthy Volunteers
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Energy expenditure measured by indirect calorimetry in a calorimetric chamber | at day 1 | Energy expenditure measured by indirect calorimetry in a calorimetric chamber |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| respiratory quotient (RQ) | at day1 | Nature of the oxidized nutrients determined from the measurement of the respiratory quotient |
| Actimetry | at day 1 | Estimated ambulatory energy expenditure from heart rate |
| HGPO | at day 1 | Charges of blood insulin concentration, and glucose in response to oral glucose load |
Countries
France
Contacts
Primary ContactPatrick LACARIN
Outcome results
None listed