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Utilizing GI: Exploring an Optimum Glycaemic Profile for Cognitive Function Across the Day

Utilizing GI: Exploring an Optimum Glycaemic Profile for Cognitive Function Across the Day in Healthy Individuals

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT03346746
Enrollment
40
Registered
2017-11-17
Start date
2017-02-01
Completion date
2017-08-30
Last updated
2017-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cognitive Performance, Glucose, High Blood, Glucose, Low Blood, Mood

Keywords

cognition, glycaemic, mood, diet

Brief summary

This study provides participants with two diets that vary in their glycaemic index values (low vs. high), whilst also measuring cognitive performance and mood.

Detailed description

Therefore, the current study introduces cognitive testing into study procedures. Participants will consume the favourable and unfavourable conditions (each containing three meals) on separate days following a crossover, randomised, couterbalanced design. The primary dependent variable is cognitive function, whilst secondary measures include glucose and mood. It is hypothesised that the favourable meal profile will be associated with cognitive and physiological benefits relative to the unfavourable meal profile.

Interventions

DIETARY_SUPPLEMENTLow Glycaemic Diet

This intervention was a diet that provided participants with three meals with a low GI value. These meals were breakfast (9am), lunch (midday) and a snack (3pm).

DIETARY_SUPPLEMENTHigh Glycaemic Diet

This intervention was a diet that provided participants with three meals with a high GI value. These meals were breakfast (9am), lunch (midday) and a snack (3pm).

Sponsors

Matthew Grout
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)

Masking description

Participants were not told what diet they were consuming each day.

Intervention model description

All participants took part in both conditions.

Eligibility

Sex/Gender
ALL
Age
18 Years to 25 Years
Healthy volunteers
Yes

Inclusion criteria

* Aged between 18 and 25 years of age * Willing to participate in the entire study (signed informed consent required) * Male or female (not pregnant)

Exclusion criteria

* Suffer from diabetes * Are anaemic * Smoker * Have any food intolerances or allergies * History of alcohol or drug misuse * Diagnosed with any of the following; * High blood cholesterol * High blood pressure * Thyroid disorder * Heart problems, stroke or any vascular disease in the past 12 months * Inflammatory diseases such as rheumatoid arthritis * Bone related conditions, such as osteoporosis * Renal, gastrointestinal, respiratory, liver disease or cancer * You are presently taking part in another clinical trial or research study * You are an elite athlete (very high intensity training more than 3 times a week) * You are currently on a specific diet, and are unwilling to cease during the testing period * You are intending to regularly use medication which affects gastrointestinal motility

Design outcomes

Primary

MeasureTime frameDescription
Change in cognitive performance between time points assessedThis was tested 9 times a day, with two days, giving a total of 18 times. Each battery of four tasks lasted approximately 15 minutesA participants performance over four cognitive tasks

Secondary

MeasureTime frameDescription
Glycaemic profileThis was measured 23 times a day, for two days, giving a total of 46 timesGlucose concentration levels
Mood (alertness, anxiety and contentment) using the Bond-Lader (1974) Visual Analogue ScaleThis takes approximately 5 minutes to complete. Participants were tested six times a day. There were two test days. Giving a total of 12 times, or approximately 60 minutes of mood scale completion.This was comprised of three mood sub-factors; alertness, anxiety, contentment. The VAS provides participants with 16 lines (100mm in length). At each end of every line are two words opposite in meaning, for example 'alert' and 'drowsy'. A participant marks each line closer to the word they feel at that current time. The minimum score is 0 and the maximum is 100, measured in millimetres.
SleepinessThis takes approximately 30 seconds to complete. Participants were tested six times a day. There were two test days. Giving a total of 12 times, or approximately 6 minutes overall.This was measured on a custom Visual Analogue Scale. Participants were presented with a 100mm line. At one end the word 'sleepy' appeared, and at the other end 'not sleepy' was present. Participants indicated how sleepy they felt by marking the line closer to the word they currently felt. Scores fell between 0 and 100.
HungerThis takes approximately 30 seconds to complete. Participants were tested six times a day. There were two test days. Giving a total of 12 times, or approximately 6 minutes overall.This was measured on a custom Visual Analogue Scale. Participants were presented with a 100mm line. At one end the word 'hungry' appeared, and at the other end 'not hungry' was present. Participants indicated how hungry they felt by marking the line closer to the word they currently felt. Scores fell between 0 and 100.
FullnessThis takes approximately 30 seconds to complete. Participants were tested six times a day. There were two test days. Giving a total of 12 times, or approximately 6 minutes overall.This was measured on a custom Visual Analogue Scale. Participants were presented with a 100mm line. At one end the word 'full' appeared, and at the other end 'not full' was present. Participants indicated how full they felt by marking the line closer to the word they currently felt. Scores fell between 0 and 100.

Countries

United Kingdom

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026