Emergency Medical Services and Epilepsy in Switzerland

Treatment of Epilepsy in Children and Adults in the Emergency Medical Services of the City of Zurich, Switzerland - Midazolam Versus Diazepam - A Retrospective Analysis

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03346382

Enrollment

584

Registered

2017-11-17

Start date

2015-03-01

Completion date

2016-06-30

Last updated

2017-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Epilepsy

Keywords

Epilepsy, Emergency medical services

Brief summary

Retrospective data analysis, all emergency medical services of the city of Zurich interventions due to epileptic convulsions during June 2013 and December 2014 have been analyzed regarding the type of drug used, its application mode and the application mode based success. Furthermore, children versus adults were compared. Continuous variables were summarized as mean ± standard deviation (SD) and also presented as median \[minimum; maximum\]. Groups were compared using the independent samples t-test. P-values \< 0.05 are considered significant.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

No minimum to 99 Years

Inclusion criteria

* emergency calls for epileptic seizures received by the emergency medical system of Zurich,Switzerland, * the use of midazolam or diazepam or no drug used.

Exclusion criteria

* the use of any other first line drug to stop seizures than the two mentioned above e.g. thiopental

Design outcomes

Primary

Measure	Time frame	Description
Which drug (Midazolam versus Diazepam) better stops epileptic seizures in the pre-clinical setting	follow up up to 1 year	In this retrospective trial, all Emergency Medical Services of the city of Zurich interventions due to epileptic seizures during June 2013 and December 2014 are analyzed regarding the two drugs (Midazolam or Diazepam) used, its application mode (intravenous, nasal, intramuscular, rectal) and the application mode based success. Data will be collected regarding these aspects in order to determine if one drug is better than the other one, and which application mode is the most efficient. Furthermore, children versus adults are compared. Continuous variables are summarized as mean ± standard deviation (SD) and also presented as median \[minimum; maximum\]. Groups are compared using the independent samples t-test. P-values \< 0.05 are considered significant.

Secondary

Measure	Time frame	Description
Does the way of application of the drugs (Midazolam versus Diazepam) used in pre-clinical epileptic seizures influence the outcome	follow up up to 1 year	In this retrospective trial, all Emergency Medical Services of the city of Zurich interventions due to epileptic seizures during June 2013 and December 2014 are analyzed regarding the two drugs (Midazolam or Diazepam) used, its application mode (intravenous, nasal, intramuscular, rectal) and the application mode based success. Data will be collected regarding these aspects in order to determine if one drug is better than the other one, and which application mode is the most efficient. Furthermore, children versus adults are compared. Continuous variables are summarized as mean ± standard deviation (SD) and also presented as median \[minimum; maximum\]. Groups are compared using the independent samples t-test. P-values \< 0.05 are considered significant.

Outcome results