miRNA Profile in Aneurysmal Subarachnoid Haemorrhage

Circulating and CSF miRNA Profile in Patients With Acute Aneurysmal Subarachnoid Haemorrhage

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03344744

Acronym

miRNA

Enrollment

100

Registered

2017-11-17

Start date

2017-11-30

Completion date

2023-08-31

Last updated

2023-09-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Subarachnoid Hemorrhage

Keywords

Subarachnoid Haemorrhage

Brief summary

The investigators aim to investigate and understand the circulating miRNA profiles after acute aneurysmal subarachnoid haemorrhage and underlying pathological significance.

Detailed description

1. The investigators aim to investigate the miRNA classifier for delayed cerebral infarction after aneurysmal subarachnoid haemorrhage; 2. The investigators aim to investigate the corresponding circulating and CSF miRNA profiles.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

21 Years to 75 Years

Healthy volunteers

Yes

Inclusion criteria

Aneurysmal subarachnoid hemorrhage patients within the first 72 hours or Healthy volunteers

Exclusion criteria

Previous neurological diseases such as stroke or dementia

Design outcomes

Primary

Measure	Time frame	Description
Circulating micro RNA concentrations	Day 3	Serum micro RNA concentrations

Secondary

Measure	Time frame	Description
Circulating micro RNA change	Days 1,2,3,7	Changes of serum micro RNA concentrations between days 1,2,3,7
Cerebrospinal fluid micro RNA concentrations	Day 1,2,3,7	Cerebrospinal fluid micro RNA concentrations
Cerebrospinal fluid micro RNA change	Days 1,2,3,7	Changes of cerebrospinal fluid micro RNA concentrations between days 1,2,3,7

Countries

China

Outcome results