The Recipients Undergoing Liver Transplantation
Conditions
Keywords
Gene polymorphism, acute kidney injury, liver transplantation
Brief summary
Some of the liver transplantation recipients experience postoperative acute kidney injury due to various causes including genetic factors. Prevention of postoperative acute kidney injury is essential for postoperative care in liver transplantation recipients. The aim of this study is to investigate the relationship between gene polymorphisms and the occurrence of acute kidney injury after liver transplantation by performing genome-wide association study (GWAS).
Interventions
None listed
Sponsors
Yonsei University
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
19 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
1\) adult patients scheduled for liver transplantation
Exclusion criteria
1. Patients on dialysis 2. patients not able to read, or understand the consent form 3. ethnicity, other than asian 4. patients refusal
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Acute kidney injury after liver transplantation | Participants will be followed up during the first 72 hours post-liver transplantation in order to confirm the development of acute kidney injury. | The development of acute kidney injury is defined by the following definition: 50% increase in SCr from the baseline (preoperative value) or a 0.3 mg/dl increase from baseline within 48 h without urine output. The development of acute kidney injury after liver transplantation could correlate with gene polymorphisms, which have been known to be associated with postoperative acute kidney injury. |
Countries
South Korea
Contacts
Primary ContactSeung Ho Choi, MD
Outcome results
None listed