Genotype-related Molecular Targets in the Vitamin D Pathway for Spinal Disc Diseases

Identification of Genotype-related Molecular Targets in the Vitamin D Pathway for Personalized Pharmacological Treatments of the Spinal Disc Diseases

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03343899

Acronym

GenVDisc

Enrollment

Registered

2017-11-17

Start date

2016-02-17

Completion date

2019-02-17

Last updated

2017-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intervertebral Disk Degeneration

Brief summary

The objective of our study will be to analyze the interplay between particular VDR variants and its ligand in cells obtained from intervertebral disc and cartilage endplate and their action on cell proliferation and phenotype maintenance. The identification of novel molecular targets in the vitamin D pathway, potentially promoting pathological alterations of the tissues involved in spinal disc diseases, will allow to develop innovative and more personalized preventive and pharmacological/nutritional therapies.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Healthy volunteers

Inclusion criteria

patients with spinal disc diseases * males and females * 18≤age ≤ 70 years old * Italian white * patients with spinal disc diseases that will be surgically treated

Exclusion criteria

\- age \< 18 or \> 70 years old

Design outcomes

Primary

Measure	Time frame	Description
Phenotype and genotype characterization	1 year	To evaluate structural alterations of the intervertebral disc and of the cartilage endplate in patients with spinal disc diseases related to functional FokI polymorphism in the vitamin D receptor (VDR) gene.

Secondary

Measure	Time frame	Description
Disc cell functional response genotype-based	2 years	To characterize cells obtained from different disc tissues (nucleus pulposus, annulus fibrosus, cartilage endplate) and to evaluate their VDR FokI genotype-related response to vitamin D treatment, regulating the cell proliferation and phenotype.

Countries

Italy

Outcome results