Parkinson Disease
Conditions
Brief summary
The aim of the study is to compare high versus low frequency rTMS on motor dysfunction in PD. Forty patients with PD participated in the study. The patients were randomly assigned into two groups; the first group received 1Hz and the 2nd one received 20 Hz rTMS daily for 10 days 5 sessions every week. The doctors who assess the patients clinically is blind for the frequency of rTMS, also patients don't know which type of stimulation they received. The patients were followed up before and after the 10 sessions and one month later.
Detailed description
The aim of the study is to compare high versus low frequency rTMS on motor dysfunction in PD. Forty patients with PD participated in the study. The patients were randomly assigned into two groups; the first group received 1Hz and the 2nd one received 20 Hz rTMS daily for 10 days 5 sessions every week and 2 days off per week. The doctors who assess the patients clinically is blind for the frequency of rTMS, also patients don't know which type of stimulation they received. The patients were followed up before and after the 10 sessions and one month later.
Interventions
DEVICErTMS
the first group received 20 Hz and the 2nd group received 1 Hz rTMS daily for 10 days 5 sessions every week on M1.
Sponsors
Assiut University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
50 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* All PD patients who were diagnosed according to UK bank criteria for PD.
Exclusion criteria
* History of repeated head injury. * History of repeated cerebrovascular strokes * History of defined encephalitis * Oculogyric crisis, supra nuclear gaze palsy. * Family history of more than one relative * severe dementia, MMSE \< 23, severe depression * Cerebellar signs * Babiniski sign * Hydrocephalus or intracranial lesion on neuroimaging * Patients with intracranial on neuroimaging * Patients with intracranial metallic device or pacemaker * Patients who were unable to give informed consent because of severe anesthesia, or cognitive deficit
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| change in motor disability | one month | Measure the change in motor disability by using UPDRS and self assessment scale |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Changes in Cortical excitability | Two weeks | Measure the changes in cortical excitability using magnetic stimulation appratus |
Countries
Egypt
Outcome results
None listed