Adapting the Diabetes Prevention Program for a Developing World Context

Conditions

Weight Loss

Brief summary

This study will examine whether an adapted version of \]he Diabetes Prevention Program (DPP) can be effective when delivered by community health workers (CHWs) in a poor urban community in South Africa. We will randomize existing groups that are part of an non-governmental organization's (NGO) chronic disease management program (anticipated cluster N = 54; anticipated individual N=540), to receive either the program or usual care (wait-list). The primary outcome analysis will compare percentage of baseline weight loss at Y1 between the program and usual care; however, after Y1 usual care participants will also receive the program and both groups will be followed for another year.

Materia FT, Smyth JM, Puoane T, Tsolekile L, Goggin K, Kodish SR, Fox AT, Resnicow K, Werntz S, Catley D.

2023-08-1010 citations

10.1186/s12889-023-16388-y

Cost-effectiveness of <i>Lifestyle Africa</i> : an adaptation of the diabetes prevention programme for delivery by community health workers in urban South Africa

Melanie D. Whittington, Kathy Goggin, Lungiswa Tsolekile, Thandi Puoane, Andrew T. Fox et al. (14 authors)

Global Health Action2023-05-239 citations

10.1080/16549716.2023.2212952

Evaluation of an adapted version of the Diabetes Prevention Program for low- and middle-income countries: A cluster randomized trial to evaluate “Lifestyle Africa” in South Africa

Delwyn Catley, Thandi Puoane, Lungiswa Tsolekile, Ken Resnicow, Kandace Fleming et al. (12 authors)

PLoS Medicine2022-04-1544 citations

10.1371/journal.pmed.1003964

Adapting the Diabetes Prevention Program for low and middle-income countries: protocol for a cluster randomised trial to evaluate ‘Lifestyle Africa’

Delwyn Catley, Thandi Puoane, Lungiswa Tsolekile, Ken Resnicow, Kandace Fleming et al. (11 authors)

BMJ Open2019-11-0121 citations

10.1136/bmjopen-2019-031400

Interventions

BEHAVIORALLifestyle Program

Participants will receive group weight loss sessions addressing healthy eating, exercise, and weight loss principles adapted from the Diabetes Prevention Program delivered by Community Health Workers.

OTHERUsual Care

Usual care consists of chronic disease management through medication delivery and monitoring of weight, blood pressure, and blood glucose by Community Health Workers.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Intervention model description

After the end of year 1 outcomes the control arm crosses over and a year 2 follow-up is conducted on both arms.

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

No

Inclusion criteria

* member of participating partner NGO health club (members are medically stabilized individuals with diabetes mellitus or hypertension referred for disease and lifestyle management) * BMI greater than or equal to 25 kg per meter squared

Exclusion criteria

* unsafe level of blood pressure (greater than or equal to 160 (systolic) and greater than equal to 100 mm (diastolic)) at screening * elevated blood sugar (A1C greater than 11) at screening * being pregnant, breast-feeding or planning pregnancy within 2 years * chronic use of oral steroid medication * intellectual disabilities that would prevent ability to understand the program * not intending to stay in the health club over the next 2 years

Design outcomes

Primary

Measure	Time frame	Description
Weight loss	1 year	percentage weight loss (weight measured in kilograms)

Secondary

Measure	Time frame	Description
Blood pressure	1 year	systolic blood pressure (mmHG), diastolic blood pressure (mmHG)
HbA1c	1 year	percent
LDL cholesterol	1 year	mg/dl
Triglycerides	1 year	mg/dl

Countries

South Africa

Outcome results

None listed