ARDS, Sepsis, Traumatic Brain Injury
Conditions
Brief summary
To observe the effect of PEEP on CVP among patients with different respiratory compliance
Detailed description
30 patients with mechanical ventilation and inserted central venous line will be entered. After gathering demographic data, patients undergone 5,10 and 15cmH2O PEEPs and the respective CVPs of the mentioned points will be recorded. According to the change of CVP, the patients will be divided into high response group and low response group, then comparing the lung compliance and thorax elastic resistance differences between the two groups.
Interventions
OTHER5,10 and 15cmH2O positive end expiratory pressure
every patients undergo 5,10 and 15cmH2O positive end expiratory pressure,and observe the central venous pressure of the mentioned points
Sponsors
Jingyuan,Xu
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
1\. Patients with mechanical ventilation and inserted central venous line
Exclusion criteria
1. The age is less than 18 years old or more than 80 years old； 2. Pregnant and lying-in woman； 3. Patients undergoing fluid resuscitation and the speed is more than 200ml/h； 4. Patients with norepinephrine dose are greater than 15 micro per minute； 5. Patients with pericarditis、pulmonary heart disease、right heart failure、atrial fibrillation； 6. Patients with COPD(endogenous PEEP is more than 2cmH2O)、tension pneumonthorax、acute episode asthma
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| CVP | half an hour | Measure the central venous pressure of the three level PEEPs of 5,10 and 15cmH2O. |
Countries
China
Contacts
Primary Contactchenglong liang, master
Backup Contactyi yang, doctor
Outcome results
None listed