Hip Disease
Conditions
Brief summary
This study aims to compare the effectiveness of liposomal bupivacaine (LB) versus standard of practice local injection containing plain bupivacaine.
Detailed description
Investigation of liposomal bupivacaine to determine if this drug is a valid alternative to standard of care local anesthesia based on evaluation in total hip arthroplasty This is a retrospective cohort study of consecutive patients undergoing THA at 3 hospitals within a U.S. healthcare system from January 2013 to July 2016. The control group received the standard of care undergoing THA (plain bupivacaine or ropivacaine), while the LB group received a mixture containing this drug as the alternative to the standard care. The outcome variables include hospital length of stay, readmissions, total hospital costs, patient pain scores, discharge disposition, morphine equivalent opioid consumption, and postoperative patient ambulation. Generalized linear models were employed to examine aforementioned outcomes controlling for age, gender, race, BMI, alcohol use, tobacco use, and surgeons..
Interventions
Replace bupivacaine with bupivacaine liposome
Sponsors
University of Illinois College of Medicine at Peoria
OSF Healthcare System
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Males or females over the age of 18 * have undergone a THA surgery during the period of interest January 2013 to July 2016).
Exclusion criteria
* excluded from the study based on the following criteria: 1. Concurrent, painful, physical condition or concurrent surgery that may require analgesic treatment in the postoperative period for pain that is not strictly related to the surgical treatment; 2. Uncontrolled anxiety, schizophrenia, or other psychiatric disorder; and 3. Significant renal or hepatic insufficiency.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Comparing physical function of the control group with the experimental group | 43 months | distance in feet walked |
| Comparing length of stay in acute care facility of the control group with the experimental group | 43 months | number of days |
| Comparing total hospital costs of the control group with the experimental group | 43 months | Number of dollars |
Outcome results
None listed