OPCABG
Conditions
Keywords
RIPC, myocardial protective effect
Brief summary
The purpose of the study was to verify the myocardial protective effect of RIPC in patients undergoing OPCABG.
Detailed description
66 patients scheduled for OPCABG are randomly assigned to a RIPC group(n=33) or a control group(n=33). In the RIPC group, 4 cycles of 5-min ischemia(using a blood pressure cuff inflated to 40mmHg over the patient's basic blood pressure) and 5-min repercussion are done on an upper limb before skin incision. Patients in the control group wear the same cuff on an upper limb but no pressure is applied. Anesthetic and surgical techniques are standardized during the trial. Serum inflammatory cytokines and cardiac injury markers will be measured before and after surgery. Internal mammary artery and saphenous vein tissues will be collected during the surgery to assess hypoxia-inducible factor (Hif)-1a and other signalling proteins.
Interventions
OTHERRIPC
4 cycles of 5-min ischemia(using a blood pressure cuff inflated to 40mmHg over the patient's basic blood pressure) and 5-min repercussion are done on an upper limb before skin incision.
Sponsors
Shanghai Zhongshan Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* serious changes in several coronary arteries that need to receive OPCABG * NHYA II-III * ASA II-III
Exclusion criteria
* LVEF\< 35% * acute myocardial infarction * multiple organ dysfunction
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| ICU staying time | average of 1 year | the time patients spend in ICU after surgery |
Countries
China
Contacts
Primary ContactKe-fang Guo, Phd
Outcome results
None listed