Lung Mass, Lung Nodules
Conditions
Keywords
dielectric property, lung nodules, differential diagnosis, frozen pathological examination
Brief summary
Patients with lung nodules/mass found by CT (computed tomography) or PET (positron emission tomography) who agree to receive lung resection are arranged to test the dielectric property before receiving the frozen pathological examination. And the final pathological results are recognized as the standard diagnosis. Then the sensitivity and specificity of the dielectric property test will be evaluated comparing with the frozen pathological examination.
Interventions
DIAGNOSTIC_TESTdielectric property test
Test the dielectric property of resected lung nodules/mass through a touching probe after the lung tissue with nodules/mass has been resected and cut open, which usually takes only 1-5 minutes.
DIAGNOSTIC_TESTfrozen pathological examination
And after the dielectric property test, the lung tissue will be sent for frozen pathological examination.
DIAGNOSTIC_TESTfinal pathological examination
All of the lung nodules/mass will be diagnosed by final pathological examination and recognized as the final diagnosis after surgery.
Sponsors
Nanfang Hospital, Southern Medical University
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Intervention model description
self-control method
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients with lung nodules/mass found by CT or PET who agree to receive lung resection; * Diameter of the lung nodule/mass is longer than 8 millimeters; * More than 50% of the lung nodule/mass is solid component by image examination; * Diameter of the solid component is longer than 5 millimeters by intraoperative exploration.
Exclusion criteria
* Cutting open the resected nodule/mass will interfered with the pathological examination; * Diameter of the solid component is shorter than 5 millimeters by intraoperative cutting open; * Cutting open the lung nodule/mass will cause great damage to the patient, such as inducing allergic shock.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| sensitivity of dielectric property test in diagnosing lung nodules/masses | 3-5 years | true positive rate in diagnosing lung nodules/masses |
| specificity of dielectric property test in diagnosing lung nodules/masses | 3-5 years | true negative rate in diagnosing lung nodules/masses |
Countries
China
Contacts
Primary ContactDi Lu, MD,PhD
Backup ContactSiyang Feng, MD
Outcome results
None listed