Cardiac Injury in Patients With Influenza

Prevalence and Prognostic Implications of Cardiac Injury in Patients With Influenza-like Illness

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03339180

Enrollment

466

Registered

2017-11-13

Start date

2017-10-01

Completion date

2023-12-31

Last updated

2022-09-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Influenza, Human, Myocardial Injury

Keywords

cardiac troponin

Brief summary

This study investigate the prevalence of elevated biomarkers of cardiac injury in patients with suspected influenza infection and the prognostic implication on the composite endpoint of death of any cause, hospitalization due to myocardial infarction, unstable angina, heart failure and stroke.

Detailed description

The relationship between influenza and cardiovascular events was described in an early study of influenza epidemics from 1915 to 1929 including the 1918-1920 pandemic. Retrospective studies have shown increased risk for acute myocardial infarction (AMI) during the first week following an infection with influenza. Biochemical markers of cardiac injury such as high sensitive cardiac troponins may be increased during infection with influenza. Increased levels of cardiac troponins are associated with adverse outcome in many different populations.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Adult patients (\>18 years) presenting with influenza-like illness. * Written informed consent.

Exclusion criteria

* Inability to provide informed consent. * Age \<18 years. * Symptoms indicating an acute coronary syndrome, acute heart failure, rapid atrial fibrillation or acute stroke.

Design outcomes

Primary

Measure	Time frame	Description
Level of biochemical markers	One year	Level of cardiac troponin in patients with influenza The level of hs-cTn, NT-proBNP and hs-CRP at inclusion in patients with and patientes without influenza.

Secondary

Measure	Time frame	Description
Prognostic implication	One year	Time to all-cause death

Countries

Sweden

Outcome results