Endometrial Hyperplasia and Endometrial Cancers
Conditions
Brief summary
Several molecular studies showed chromosomal alterations in patients with endometrial cancer, with gains in 1q, 19p, 19q, 8q, 10q and 10p and loss of 4q, 16q and 18q. Several genes of interest have been identified (P53, PTEN, PIK3CA, ß-catenin, K-ras ...). A study has already been carried out at the Reims University Hospital with inclusion of patients with endometrial cancer and patients with endometrial hyperplasia. It identified specific alterations of nosologic continuum of pathology and characterize areas of interest on the genome.
Detailed description
make a pangenomic investigation of genetic abnormalities in atypical endometrial hyperplasia and endometrial cancers.
Interventions
GENETICGenetic analysis
Genetic analysis of the samples taken during the surgery (hysterectomy or curettage resection) using CGH array technique.
Sponsors
CHU de Reims
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* patient with endometrial hyperplasia or endometrial cancer * patient consenting to participate to the study * patient enrolled in the national healthcare insurance program * patient older than 18 years
Exclusion criteria
\- patient with neoadjuvant chemotherapy or radiotherapy prior to surgery
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Genetic imbalances | Day 0 | Genetic aberrations detected by comparative genomic hybridization (CGH arry) |
Countries
France
Contacts
Primary ContactEmilie RAIMOND
Outcome results
None listed