Brain Diseases
Conditions
Keywords
MRI, Neuroradiology, minute-MRI, multi EPI-mix, Clinical Validation
Brief summary
This study aims to assess the diagnostic validity of a new minute-MRI sequence for neuroradiological evaluation in comparison to conventional MRI.
Detailed description
The study aims to assess the imaging quality with regards to artefacts and lesion conspicuity as well as its diagnostic potential in rendering a probable diagnosis. The primary study aim is to define the AUC for diagnostic performance of minute MRI compared to conventional MRI. Included patients are those with suspiscion of cerebral pathology. Study participancts are investigated at 3T.
Interventions
DIAGNOSTIC_TESTMRI
MRI sequence without intravenous contrast
Sponsors
GE Healthcare
Karolinska University Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
\- Neuroradiological MRI
Exclusion criteria
\- Aborted exam
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Diagnostic potential | At MRI scan. Diagnostic accuracy to categorize scan as normal or abnormal on a five point Likert scale compared to abnormal/normal conventional MRI. | Diagnostic performance of lesion conspicuity of new MR sequence compared to conventional sequences |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Lesion classification | At MRI scan | Classification into disease categories |
| Imaging quality | At MRI scan | Artefacts |
| Diagnostic imaging quality | At MRI scan | Diagnostic imaging quality |
| Anatomical conspicuity | At MRI scan | Specified anatomical structures |
| Multifocality | At MRI scan | Determine multifocal lesion |
| Lesion location determination | At MRI scan | Anatomical localization of abnormality |
| Lesion description | At MRI scan | For example effect on brain parenchyma and size |
| Diagnostic confidence | At MRI scan | Scale |
| Brain coverage | At MRI scan | Full or lower |
| Clinical diagnostic summay report | At MRI scan | Text |
| Ability to rule out diseases | At MRI scan | A list of diseases |
Countries
Sweden
Outcome results
None listed