CRC
Conditions
Brief summary
All the preoperative biopsies of patients suffering colorectal cancer (CRC) will be immunohistochemically stained with a pancytokeratin marker to detect Tumor buds. then, the intratumoral buds (ITB) in the densest Region of Tumor buds, namely the "hot spot" will be counted. Subsequently, the probability of N stage (lymphnodes), M stage (metastases) and disease free survival (DFS) will be calculated based on an existing logistic Regression model already developed by our previous retrospective work. Additionally, a Standardisation of ITB using a well- established Software will develop an algorithm which will help to eliminate inter- observer variability of Tumor budding Counts.
Interventions
None listed
Sponsors
Insel Gruppe AG, University Hospital Bern
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
* Patients with newly diagnosed stages I and IV colorectal cancer (CRC) * Age ≥ 18 years * Written Informed Consent
Exclusion criteria
* No consent * \< 18 years
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| correlation of ITB based calculated N stage with real N stage in CRC - patients | 24 months |
Secondary
| Measure | Time frame |
|---|---|
| correlation of ITB based calculated DFS with real DFS in CRC - patients | 24 months |
Countries
Switzerland
Contacts
PRINCIPAL_INVESTIGATORBeat Schnüriger, PD
Insel Gruppe AG, University Hospital Bern
Outcome results
None listed