Effect of Weight Reduction on Immunity

Reduction of Natural Killer Cell (CD16/56) and T-lymphocyte (CD3) Subset Counts After a Weight Loss Program Using Anti-obesity Drugs in Obese Women: a Non-randomized Controlled Trial

Status

Completed

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03336086

Enrollment

Registered

2017-11-08

Start date

2012-03-20

Completion date

2012-12-25

Last updated

2017-11-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lymphocytes, Weight Loss, Viral Diseases, Immunity, Anti-obesity Agents

Brief summary

This study included two groups of premenopausal healthy obese women. Experimental group underwent a weight loss program involved a low calorie diet plus anti-obesity drugs and moderate physical activity and control group underwent an ad libitum diet. At baseline and after a 10-15% weight loss lymphocyte subgroups were analyzed and compared between two group.

Detailed description

TCD3 and NKC CD16/56 were decreased significantly. Hence this weight loss program impaired viral immunity

Interventions

COMBINATION_PRODUCTweight loss program

A low calorie diet+ Orlistat+ Soluble Fiber+ Physical activity

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

OTHER

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

FEMALE

Age

20 Years to 45 Years

Healthy volunteers

Yes

Inclusion criteria

* BMI \>=30 * female * healthy * no smoking * not lactating * not pregnant * no medication use

Exclusion criteria

* pregnancy * any disease * any medication use * iron and zinc deficiency * any supplement use

Design outcomes

Primary

Measure	Time frame	Description
lymphocyte subgroups	6 months	TCD3. TCD4. TCD8. BCD19. NKCs CD16/56 (Cells/microliter) by flowcytometry

Secondary

Measure	Time frame	Description
Biomarkers	6 months	ZN, Iron (microgram/deciliter) by biochemical assessment
Systolic blood pressure	6 months	(mmHg) by manometer
diastolic blood pressure	6 months	(mmHg) by manometer
Weight	6 months	(Kg) by Bioelectric impedance analyser
Body Mass Index	6 months	(Kg/m\^2) by equation
Fat Free Mass	6 months	(Kg) by Bioelectric impedance analyser
Trunk Fat	6 months	(Kg) by Bioelectric impedance analyser
Waist circumference	6 months	(cm) by meter tape
Fat Mass	6 months	(Kg) by Bioelectric impedance analyser

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026