Affective Disorders, Cognitive Impairment, Dementia
Conditions
Keywords
Epidemiology, Magnetic resonance imaging, Diffusion tensor imaging, White matter, Functional MRI, Connectome, Resting state brain networks, Neuropsychology
Brief summary
Follow-up study within the Whitehall II study, selecting 800 participants for further neuropsychological, clinical and imaging (MRI) examinations to examine brain structure and function in relation to age-related diseases and the modifiable and non-modifiable factors affecting resilience against and vulnerability to adverse brain changes.
Detailed description
A total of 6035 civil servants participated in the WHII Phase 11 clinical examination in 2012-2013. A random sample of 800 of these participants was included in a sub-study comprising an MRI brain scan, a detailed clinical and cognitive assessment, and collection of blood and buccal mucosal samples for the characterisation of immune function and associated measures. Data collection for this sub-study started in 2012 and was completed by in 2016. The participants, for whom social and health records have been collected since 1985, were between 60-85 years of age at the time the MRI study started. The pre-specified clinical and cognitive assessment protocols, the state-of-the-art MRI sequences and latest pipelines for analyses of this sub-study have been published and are attached to this application.
Interventions
None listed
Sponsors
University College, London
University of Oxford
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
* Member of Whitehall II cohort attending at UCL for phase 11
Exclusion criteria
* Not suitable for MRI, travelling to Oxford, seriously physically ill
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Neuropsychological measure 1 | 2012-2016 | National Adult Reading Test (premorbid intellectual ability) |
| MRI Measures 2 | 2012-2016 | Siemens 3T - T1-weighted scan (MPRAGE) using FSL GLM Voxel based analysis for grey matter density analysis |
| Neuropsychological measure 2 | 2012-2016 | Montreal Cognitive Assessment (MoCA) |
| Neuropsychological measure 3 | 2012-2016 | Rey Complex Figure copy and delayed recall (visual episodic memory) |
| Neuropsychological measure 4 | 2012-2016 | Hopkins Verbal Learning Test Revised (verbal episodic memory) |
| Neuropsychological measure 5 | 2012-2016 | CANTAB Simple and Choice Reaction Time (processing speed) |
| Neuropsychological measure 6 | 2012-2016 | WAIS-R Digit Symbol Test (processing speed) |
| Neuropsychological measure 7 | 2012-2016 | Trail Making Test A and B (processing speed/executive functioning) |
| Neuropsychological measure 8 | 2012-2016 | WAIS-R Digit Span forward and backwards (executive functioning) |
| Neuropsychological measure 9 | 2012-2016 | Graded Naming Test (semantic memory) |
| MRI Measures 1 | 2012-2016 | Siemens 3T - T1-weighted scan (MPRAGE) using FSL FIRST, FAST, and Freesurfer Volume extractions |
| MRI Measures 3 | 2012-2016 | Siemens 3T - T2-weighted scan, clinical and FSL (BIANCA)-based rating of white matter changes |
| MRI Measures 4 | 2012-2016 | Siemens 3T Diffusion Tensor Images analyzed with Tract Based Spatial Statistics (TBSS) |
| MRI Measures 5 | 2012-2016 | Siemens 3T rs-fMRI analyzed with Multivariate Exploratory Linear Optimized Decomposition into Independent Components: MELODIC) |
Countries
United Kingdom
Outcome results
None listed