Antibiotics, Intensive Care, Severe Burn
Conditions
Brief summary
At antibiotic stewardship of the University Hospital of Schleswig-Holsten it was noticed that there are much less studies measuring drug levels in severe burned patients than are required. Especially, severe burned patient developing a capillary leak might show lower drug levels than patients without a capillary leak. To compare drug levels of beta-lactam antibiotics, it is the aim of this study to measure pharmacokinetics of Piperacillin/Tazobactam in ICU patients with and without severe burns.
Interventions
DIAGNOSTIC_TESTDrug Level Monitoring
Free (unbound) drug concentration 1 hour, 4 hours and 7.5 hours after primary load of piperacillin/tazobactam on day 1 and day 3 after admission
Sponsors
Medical Clinic III
Dezernat Apotheke
University Hospital Schleswig-Holstein
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
General * Adult * Receiving beta-lactam antibiotic Piperacillin/Tazobactam * Antibiotic therapy of 3 or more days * Given informed consent Group 1 * Severe Burn Group 2 * No Severe Burn
Exclusion criteria
* Already in another Study * No useful blood sample
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Free (unbound) drug concentration 1 hour, 4 hours and 7.5 hours after primary load of piperacillin/tazobactam on day 1 and day 3 after admission | 1 hour, 4 hours and 7.5 hours after primary load of piperacillin/tazobactam on day 1 and day 3 after admission | Free (unbound) drug concentration 1 hour, 4 hours and 7.5 hours after primary load of piperacillin/tazobactam on day 1 and day 3 after admission |
Countries
Germany
Outcome results
None listed