Incomplete Total Body Protein Recovery in Adolescent Patients With Anorexia Nervosa

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03334032

Enrollment

154

Registered

2017-11-07

Start date

2004-07-31

Completion date

2010-07-31

Last updated

2017-11-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anorexia Nervosa

Keywords

Body composition, Total body protein, nutritional recovery, Exercise status, In-vivo neutron activation analysis, Protein depletion

Brief summary

The study aimed to assess protein accretion during weight gain in adolescent patients with Anorexia nervosa

Detailed description

Background: Bone health and growth during adolescence require adequate Total Body Protein (TBPr). Re-nutrition for patients with anorexia nervosa (AN) should aim to normalize body composition, i.e. recovery of fat mass and TBPr. Objective: The study intended to analyze predictors of protein status, including exercise status, in adolescents with AN, and to investigate whether weight gain would replete body protein deficits. Methods: The investigators assessed TBPr in a longitudinal, observational study as height-adjusted nitrogen index (NI) using in-vivo neutron activation analysis in adolescents with AN at the commencement of refeeding (T0), as well as seven months thereafter (T1), and in age-matched normal weight controls. Lean tissue and fat mass were assessed with Dual-Energy X-Ray Absorptiometry (DXA). BMI, BMI-SDS and lean tissue mass were tested as predictors of protein status using Receiver Operating Characteristic (ROC) analysis.

Interventions

OTHERInpatient treatment for Anorexia nervosa

Nutritional rehabilitation in a clinic with specialized eating disorder service

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

12 Years to 19 Years

Healthy volunteers

Yes

Inclusion criteria

Patient Inclusion Criteria: * diagnosis of anorexia nervosa (DSM-IV) * aged 12 - 19 years * female gender Patient

Exclusion criteria

\- existence of a further disease with effect on body composition Controls: * no known disease * normal weight

Design outcomes

Primary

Measure	Time frame	Description
Change in Total Body protein	Between baseline (inpatient admission) and at 7 months follow-up	Change in Total Body protein

Secondary

Measure	Time frame	Description
Change in body weight	Between baseline (inpatient admission) and at 7 months follow-up	Change in: body weight (kg)
Change in Body Mass Index	Between baseline (inpatient admission) and at 7 months follow-up	Change in Body Mass Index (BMI; kg/m2)
Change in body fat mass	Between baseline (inpatient admission) and at 7 months follow-up	Change in body fat mass (kg)
Change in body lean tissue mass	Between baseline (inpatient admission) and at 7 months follow-up	Change in body lean tissue mass (kg)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026