PreDiabetes
Conditions
Brief summary
The researchers investigated the anti-diabetic effects of Allium hookeri root extract for Korean prediabetic participants.
Detailed description
Allium hookeri root is widely consumed as a vegetable and herbal medicine in Asia. Although the antidiabetic activities of Allium hookeri have been documented in animal studies, the improved effects of Allium hookeri on human are not clear. Therefore, in this study, the researchers investigated whether Allium hookeri root extract could be effective in reducing the risk of type 2 diabetes in individuals with prediabetes.
Interventions
DIETARY_SUPPLEMENTAllium hookeri extract
take two capsules per day (486 mg/day) for 8 weeks
DIETARY_SUPPLEMENTPlacebo
take two capsules per day
Sponsors
Chonbuk National University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
20 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* Fasting glucose 100\ 126 mg/dl
Exclusion criteria
* Significant variation in weight (more 10%) in the past 3 months * Treatment by hypoglycemic and hypolipidemic drug therapy within the past three months * Type 1 diabetes or HbA1c\>9.0% * Cardiovascular disease * Hypoglycemic agent, obesity medicine, and lipid lowering agent within past 6 months or blood sugar, obesity, and lipid improvement functional foods within past 2 monts * Pregnancy or breast feeding
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes of blood glucose during OGTT | 8 weeks | Changes of fasting and postprandial glucose during OGTT were assessed before and after the intervention |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Changes of HbA1c | 8 week | Changes of HbA1c were assessed before and after the intervention |
| Changes of blood insulin | 8 week | Changes of blood insulin were assessed before and after the intervention |
| Changes of C-peptide | 8 week | Changes of C-peptide were assessed before and after the intervention |
Outcome results
None listed