Acute Kidney Injury, Contrast-induced Nephropathy, IHD
Conditions
Keywords
spironolactone
Brief summary
an interventional study to measure the possible effects of spironolactone ( an aldosterone antagonist) on the incidence of acute kidney injury after coronary angiography
Interventions
DRUGSpironolactone
each patient will receive 200 mg of spironolactone as per his/her angiography premedications
DRUGPlacebo Oral Tablet
Each patient will receive a placebo tablet as per his/her angiography premedications
Sponsors
Ministry of Health-Basra Health Directorate-Al-Sader Teaching Hospital
Alhasan Mujtaba Abdul-Wahid
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* patients admitted to angiography unit * over 18 * informed consent
Exclusion criteria
* acute renal failure before 7 days * spironolactone contraindications * hyperkalemia (S.K. \>5.5 mEq/L) * documented tumor * actively taking NSAIDs, Ciclosporin, Cisplatin,
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Acute kidney injury by K-DIGO guidelines | 48-72 hrs | an absolute elevation of serum creatinine of 0.5mg/dl or 25% above baseline |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| acute kidney injury by NGAL | 6 hours | assessment of serum NGAL at admission and after 6 hrs to detect possible AKI in selected patients |
Other
| Measure | Time frame | Description |
|---|---|---|
| safety outcome: serum potassium | 6 hrs | serum potassium after 6 hrs of angio |
Countries
Iraq
Outcome results
None listed