Chronic Gingivitis, Chronic Gingivitis, Plaque Induced
Conditions
Keywords
Gingival Health, Biofilm Formation
Brief summary
This study evaluates the addition of a mouth rinse containing sea salt, xylitol and lysozyme to standardized oral health practices on biofilm formation and gingival health in a group of young adults.
Detailed description
The purpose of this study is to evaluate a new sea salt mouth rinse containing xylitol and the antibacterial enzyme, lysozyme on biofilm formation and gingival health in a group of young adults. Xylitol is a well-established non-sugar sweetener and an anti-caries agent. The use of this polyol results in loosely adherent biofilms by reducing the amount of extracellular lipopolysaccharides and lipoteichoic acids, facilitating its easy removal by mechanical means. Lysozymes are antibacterial proteins that hydrolyze the linkage between N-acetylmuramic acid and N-acetylglucosamine of peptidoglycan in the cell wall of Gram + bacteria effectively limiting growth.
Interventions
OTHERSea Salt Mouth Rinse
Rinsing mouth with a tablespoon of sea salt mouth rinse without any dilution, for 30 seconds, once in the morning and once before bed, in addition to Standardized Oral Health Practices.
OTHERStandardized Oral Health Practices
Brushing teeth for two minutes using the modified Bass technique, twice per day with the provided dentifrice, and flossing once daily using the spool method
Sponsors
University of Saskatchewan
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to 26 Years
Healthy volunteers
Yes
Inclusion criteria
* Dentate * Medically healthy * No orthodontic bands * An anticipated ability to attend the two scheduled visits
Exclusion criteria
* Significant medical condition (including but not limited to, poorly controlled diabetes mellitus, rheumatic heart disease or clinically significant heart murmur) * Pregnancy * Recent history of, or ongoing, antibiotic therapy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Turesky modification of Quigley-Hein plaque index | Change from Baseline at 1 Month | Evaluation of plaque scores on six representative teeth: 16, 21, 24, 36, 41 & 44, using an index that evaluates the plaque revealed on the buccal and lingual non-restored surfaces of the teeth on a scale of 0 to 5, defined by G. A. Quigley and J. W. Hein in 1962 and modified by S. Turesky, N. D. Gilmore, and I. Glickman in 1970. |
| Presence or absence of gingival bleeding | Baseline and 1 Month | Presence or absence of gingival bleeding on gentle probing to determine gingival health |
Countries
Canada
Outcome results
None listed