Delirium of Mixed Origin, Microbial Colonization
Conditions
Brief summary
To investigate whether the composition of the gut microbiota is different in patients that develop delirium during critical illness as compared to patients who do not.
Detailed description
We plan to include an equal number of patients admitted to the ICU, that either do or don't develop delirium during their course of critical illness. Samples of feces/rectal swaps will be taken at admission and again either when the patients become CAM-ICU positive, alternatively after 5 days admssion/at discharge in patients that remain CAM-ICU negative. Samples are then sent to analyses for purification of bacterial DNA and metagenomic analysis.
Interventions
DIAGNOSTIC_TESTMetagenomic analysis of gut microbiota
All patients have rectal swaps/fecal samples subjected to metagenomic analysis
Sponsors
University of Arkansas
Herlev Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
Admission to the ICU, Disability to make informed consent due to critical illness -
Exclusion criteria
Dementia. Delirium diagnosed prior to the ICU admission on the non-ICU floors. Coma. Indication for deep sedation (-4/-5). \-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Gut Microbiota composition | May 2018 | Metagenomic analysis of Gut Microbiota / composition by different bacterial families |
Outcome results
None listed