Postoperative Pain
Conditions
Brief summary
TAP-block has been shown to be a safe and effective postoperative analgesia method in a variety of general. Dexmedetomidine is a selective α2 agonist with 8 times more affinity for α2 adrenergic receptors compared to clonidine and possesses all the properties of α2 agonist without respiratory depression. Dexmedetomidine has been focus of interest for its broad spectrum (sedative, analgesic and anesthetic sparing) properties, making it a useful and safe adjunct in many clinical applications.
Interventions
DRUGDexmedetomidine
20 ml of 0.5 % bupivacaine plus dexmedetomidine 1 μg•kg-1
DRUGbupivacaine
20 ml of 0.5 % bupivacaine
Sponsors
Assiut University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* 24 ASA I-II * patients (age 18-60 years * weight 50-89 kg
Exclusion criteria
* a known allergy to the study drugs * significant cardiac * respiratory, renal or hepatic diseases * bleeding diathesis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| measure dexmedetomidine level into systemic circulation after local administration | up to 6 hours | assessment of systemic dexmedetomidine level after local administration in TAP block after 15 minutes after giving the block, 30 min, 45 min, 1hrs, 2hrs, 4hrs and 6 |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| total dose of IV PCA morphine consumption in the first 24 h postoperative | 24 hours | postoperative morphine consumption |
Countries
Egypt
Outcome results
None listed