Chronic Pancreatitis, Complication, Risk Factors
Conditions
Brief summary
Chronic pancreatitis (CP) is a disease characterized by inflammation and their replacement by fibrotic tissue. The destruction of pancreatic function and structure are the main complications. This retrospective-prospective, multicenter, cohort study was conducted. This study aimed to observe the natural history of CP in China, analyse the risk factors for CP complications, and establish individual predictions.
Detailed description
In order to track changes consistently throughout the course of CP and facilitate the evaluation and study of CP, a dedicated database, CP Database (version number 2.1, YINMA Information Technology Inc., Shanghai, China), was established to collect clinical data of CP patients who were admitted to our centers. Data befor CP Database established were retrospectively collected according to the electronic medical record system and complemented through telephone, letter, and e-mail inquiries. Data were prospectively collected since CP Database was established. The following information was documented in detail: demographic data (age, sex, birthplace, et al), course of CP, medical history, history of other diseases, smoking and alcohol history, family history of pancreatic diseases and diabetes mellitus (DM), laboratory and imaging findings, and treatment strategy.
Interventions
None listed
Sponsors
Changhai Hospital
Shenzhen People's Hospital
Zhongda Hospital
The Affiliated Hospital of Qingdao University
Yangzhou University
Jinling Hospital, China
The First People's Hospital of Hefei
Zaozhuang Central Hospital of Shandong Health Group
The Fifth Medical Center of the PLA General Hospital
The Third People's Hospital of Chengdu
Ruijin Hospital
900th Hospital of PLA Joint Logistic Support Force
Air Force Medical Center of PLA
The Fifth Medical Center of Chinese People's Liberation Army General Hospital
The Affiliated Hospital of Technical University of Munich
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Patients diagnosed with chronic pancreatitis according to Asia-Pacific consensus
Exclusion criteria
* Pancreatic cancer diagnosed within 2 years after the diagnosis of chronic pancreatitis * Groove pancreatitis * Autoimmune pancreatitis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pancreatic cancer | Dec 31, 2017 | Pancreatic cancer developed in chronic pancreatitis patients |
| Diabetes mellitus | Dec 31, 2017 | Endocrine insufficiency developed in chronic pancreatitis patients |
| Steatorrhea | Dec 31, 2017 | Exocrine insufficiency developed in chronic pancreatitis patients |
| Pancreatic pseudocyst | Dec 31, 2017 | Pancreatic pseudocyst developed in chronic pancreatitis patients |
| Common bile duct stricture | Dec 31, 2017 | Common bile duct stricture developed in chronic pancreatitis patients |
Countries
China
Outcome results
None listed