ADHD
Conditions
Brief summary
The goal of the current project is to assess the efficacy of Central Executive Training (CET) for youth with ADHD. CET is a new, computerized training intervention that targets specific components of the working memory system. Two versions of CET were developed as part of our R34, each targeting a different combinations of executive functions. The final CET protocol reflects the contributions and feedback of a diverse group of caregivers, children with ADHD, and recognized experts in human cognition, ADHD treatment research, randomized control trial (RCT) intervention design methods, serious game theory and task design, cognitive training, and the role of executive dysfunction in ADHD.
Interventions
BEHAVIORALCentral Executive Training: Working Memory
Computerized working memory training
BEHAVIORALCentral Executive Training: Inhibitory Control
Computerized inhibitory control training
Sponsors
Florida State University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
8 Years to 12 Years
Healthy volunteers
No
Inclusion criteria
* Children ages 8-12 with principal ADHD diagnoses (via Kiddie Schedule for Affective Disorders semi-structured clinical interviewing (K-SADS) * Parent AND teacher ratings in clinical/borderline range based on age and gender on ADHD-RS-5 or BASC-3 Attention Problems/Hyperactivity subscales * Below average or lower working memory on at least one pre-treatment WM test. All ADHD presentations will be eligible.
Exclusion criteria
* gross neurological, sensory, or motor impairment * history of seizure disorder, psychosis, bipolar, or severe dysregulation disorders that may interfere with study participation (substance use, disruptive mood dysregulation, intermittent explosive, reactive attachment) * intellectual disability or Wechsler Intelligence Scale for Children (WISC-V) short-form intelligence quotient (FSIQ) \< 78 (1.5 standard deviations (SD) below mean) * conditions requiring acute intervention, e.g., active suicidality * non-English speaking child or parent.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| ADHD symptoms | Immediate post-treatment (within 2 weeks of final treatment session) | Average of T-scores on parent-report ADHD symptoms questionnaires (Attention Deficit Hyperactivity Disorder Rating Scale (ADHD-5) Inattention and Hyperactivity subscales, Behavioral Assessment System for Children (BASC-3) Inattention and Hyperactivity subscales) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Working Memory | Immediate post-treatment (within 2 weeks of final treatment session) | Average of stimuli correct per trial on the Rapport phonological and visuospatial working memory tests |
| Inhibitory control | Immediate post-treatment (within 2 weeks of final treatment session) | Average of performance on the stop-signal (stop-signal delay metric) and go/no-go tests (commission errors) |
| Actigraph-measured hyperactivity during working memory testing | Immediate post-treatment (within 2 weeks of final treatment session) | Proportional integrating measure (PIM) units from autographs worn on non dominant wrist, left ankle, and right ankle during Rapport working memory tests. PIM units from each actigraph will be aggregated by summing them to create a Total Hyperactivity Score. |
| Actigraph-measured hyperactivity during baseline | Immediate post-treatment (within 2 weeks of final treatment session) | Proportional integrating measure (PIM) units from autographs worn on non dominant wrist, left ankle, and right ankle. During beginning and end of session baseline painting tasks (described in Rapport et al., 2009). PIM units from each actigraph will be aggregated by summing them to create a Total Hyperactivity Score. |
Other
| Measure | Time frame | Description |
|---|---|---|
| NIH List Sorting | Follow-up testing: 2-4 months after the post-treatment evaluation (variable time frame to account for school breaks) | Standard scores on NIH List Sorting test |
| Teacher-reported ADHD symptoms | Immediate post-treatment (within 2 weeks of final treatment session) | Average of T-scores on teacher-report ADHD symptoms questionnaires (ADHD-5 Inattention and Hyperactivity subscales, BASC-3 Inattention and Hyperactivity subscales) |
| Academic performance rating scale (APRS) | Immediate post-treatment (within 2 weeks of final treatment session) | Total score (T-score) for academic performance (teacher ratings) |
| Social Skills: Teacher Report | Immediate post-treatment (within 2 weeks of final treatment session) | Teacher-reported total score (standard score) on Social Skills Improvement System (SSIS) |
| Children's Organizational Skills Scale (COSS) Teacher Report | Immediate post-treatment (within 2 weeks of final treatment session) | Teacher-reported total organizational problems (T-score) |
| Social Skills: Parent Report | Immediate post-treatment (within 2 weeks of final treatment session) | Parent-reported total score (standard score) on Social Skills Improvement System (SSIS) |
| Kaufman Test of Educational Achievement Third Edition (KTEA-3) Math Fluency | Follow-up testing: 2-4 months after the post-treatment evaluation (variable time frame to account for school breaks) | Standard score on KTEA-3 Math Fluency subtest |
| Children's Organizational Skills Scale (COSS) Parent Report | Immediate post-treatment (within 2 weeks of final treatment session) | Parent-reported total organizational problems (T-score) |
| Parent-child relationship quality | Immediate post-treatment (within 2 weeks of final treatment session) | Parent-reported total score (T-score) on Parent Relationship Questionnaire (PRQ) |
| Kaufman Test of Educational Achievement Third Edition (KTEA-3) Reading Comprehension | Follow-up testing: 2-4 months after the post-treatment evaluation (variable time frame to account for school breaks) | Standard score on KTEA-3 Reading Comprehension subtest |
| Kaufman Test of Educational Achievement Third Edition (KTEA-3) Listening Comprehension | Follow-up testing: 2-4 months after the post-treatment evaluation (variable time frame to account for school breaks) | Standard score on KTEA-3 Listening Comprehension subtest |
| Kaufman Test of Educational Achievement Third Edition (KTEA-3) Reading Fluency | Follow-up testing: 2-4 months after the post-treatment evaluation (variable time frame to account for school breaks) | Standard score on KTEA-3 Reading Fluency subtest |
Countries
United States
Outcome results
None listed