Vascular Function
Conditions
Keywords
Energy drink consumption
Brief summary
The purpose of this study will be to examine the acute effect of commercially available energy products on endothelial function, arterial stiffness and thrombosis in healthy young males.
Detailed description
The use of energy products has significantly increased in the last few years and is especially high among young men. The present study will compare the acute effect of a commercially available energy drink, energy gum, coffee and control beverage on endothelial function, arterial stiffness and circulating markers of thrombosis, inflammation and oxidative stress.
Interventions
OTHERenergy drink
16 oz cold commercially-available energy drink
OTHERcaffeinated drink
16oz cold commercially-available caffeinated drink
OTHEREnergy gum
2 pieces of commercially-available energy gum
OTHERplacebo gum
2 pieces of commercially-available placebo gum
OTHERControl drink
16oz cold control drink
24-hour total sleep deprivation prior to consumption of energy drink and placebo gum
Sponsors
University of Florida
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
MALE
Age
18 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
* Being Male * 18-30 years of age * No indication of major clinical disease (e.g. diabetes, hypertension, significant arrhythmias, syncope and cardiovascular disease) * BMI ≤ 30 kg/m\^2 and blood pressure ≤ 140/90 mmHg * Consumption of \<400mg of caffeine/day * Prior history of consumption of energy drinks
Exclusion criteria
* Being female * Age \<18 or \>30 years * BMI\> 30 kg/m\^2 and blood pressure \> 140/90 mmHg * Use of medication that may affect vascular measures * Use of tobacco products including smoking * Vegan or vegetarian diet * Being energy drink or caffeine naïve or consumption of \>400 mg of caffeine/day * Consumption of \>1 energy drinks per month * Being a shift worker
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in endothelial function | Before and 1 and 2 hrs following consumption of drink and gum | Brachial artery flow-mediated dilation |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in wave reflection | Before and 1 and 2 hrs following consumption of drink and gum | Augmentation index |
| Change in peripheral and central blood pressures | Before and 1 and 2 hrs following consumption of drink and gum | Brachial and aortic blood pressures |
| Change in arterial stiffness | Before and 1 and 2 hrs following consumption of drink and gum | Carotid to femoral pulse wave velocity |
| Change in circulating factors related to vascular function | Before and 1 and 2 hrs following consumption of drink and gum | Circulating levels of Trimethylamine N-oxide (TMAO) and markers of oxidative stress and inflammation |
| Change in heart rhythm | Before and 1 and 2 hrs following consumption of drink and gum | Electrocardiogram |
| Change in thrombosis and platelet function | Before and 1 and 2 hrs following consumption of drink and gum | Thromboelastograph and platelet aggregation tests |
Countries
United States
Outcome results
None listed