Graves Ophthalmopathy
Conditions
Keywords
Fibroblast growth factors, Fibroblast growth factors receptors, Thyroid orbitopathy
Brief summary
Graves' orbitopathy (GO) affects about 50% of patients with Graves' disease (GD), and some cannot be cured by current treatments. Orbital fibroblasts involves in the pathogenesis of GO by producing glycosaminoglycans and inflammatory cytokines. Since fibroblast growth factors (FGFs) binding to FGF receptors (FGFRs) can induce proliferation and differentiation of fibroblasts, investigators would like to measure the expression of FGFs and FGFRs in GO patients to see if inhibition of FGF-FGFR pathway has potential in treatment.
Interventions
None listed
Sponsors
National Taiwan University Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* diagnosed as thyroid eye disease * suggested to accept orbital decompression
Exclusion criteria
* age below 20 or above 80 * pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Serum concentration of selected growth factors | 1 year | Investigators would like to measure fibroblast growth factors concentration (ug/mL) by ELISA according to the manufacturers' instruction |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| RNA expression level of selected growth factor receptors | 1 year | Investigators would like to measure growth factor receptors expression level comparing to house-keeping gene using real-time PCR |
Countries
Taiwan
Contacts
Primary ContactShyang-Rong Shih, M.D, Ph. D
Outcome results
None listed