Brain Connectivity, Hemiparesis, Stroke, Transcranial Magnetic Stimulation
Conditions
Brief summary
This study evaluates the effect of a unique session of inhibitory rTMS (cTBS) over the contralesional posterio parietal cortex (PPC) on the spatio-temporal parameters of a pointing movement performed by stroke patients with their paretic upper limb. It will also assess the effects on the resting motor threshold of both hemispheres and on parietopremotor connectivity. To achieve theses aims, the real cTBS stimulation will be randomly counterbalanced with a SHAM stimulation (in a second session) in a crossover design. Assessments will be performed before and after each stimulation session.
Interventions
DEVICErepeated transcranial magnetic stimulation continuous theta-burst stimulation
cTBS
SHAM stimulation
Sponsors
University Hospital, Lille
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Age between 18 and 80y * Right-handed * Right hemispheric stroke confirmed by a 3D imaging technique * at the chronic phase (\>6months) * subject being able to perform a pointing movement of at least 20cm in the anterior space without compensatory movements of the trunk * informed consent * Social security affiliation
Exclusion criteria
* Severe comprehension troubles (language, cognitive or psychiatric disorders) * History of neurological disorders in addition to the stroke * Locomotor troubles affecting the paretic arm * Contraindication to rTMS : epilepsy, intracranial metallic foreign body, cochlear implant, unstable fracture of the skull bones, deafness * pregnancy or breastfeeding * adult subject to guardianship
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Time of movement during the pointing movement | 30 minutes | Time between the initiation of the movement and the reaching of the target |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Reaction time (time between the go signal and th onset of the movement) | 30 minutes | temporal parameters of pointing movements |
| Response time (time between the go signal and the reaching of the target) | 30 minutes | temporal parameters of pointing movements |
| Peak velocity of the hand during the pointing movement | 30 minutes | pak velocity in m/s |
| smoothness (number of units of movement during the pointing movement), | 30 minutes | Spatial parameters of pointing movements |
| Linearity (ration between the length of the trajectory of the hand and the linear distance between the initial position of the hand and the target) | 30 minutes | Spatial parameters of pointing movements |
| Detection of mirror movements with the healthy upper limb | 30 minutes | EMG detection |
| Primary motor cortex excitability of both motor cortices | 30 minutes | Resting motor threshold of lesioned and non-lesioned hemispheres |
| Parietomotor connectivity in the contralesional hemisphere | 30 minutes | Assessed by a paired-pulse TMS protocol (see Allart et al. 2017 for more details) |
| Spatial bias | 30 minutes | Line bisection test |
Countries
France
Contacts
PRINCIPAL_INVESTIGATOREtienne Allart, MD
University Hospital, Lille
Outcome results
None listed