Infertility, Female
Conditions
Brief summary
In a prospective observational study at a university teaching hospital, blood flow indices and serum hormone levels were compared between spontaneous and stimulated cycles in the same group of 50 patients with unexplained delayed conception.
Detailed description
In a prospective observational study at a university teaching hospital, the mid-luteal (peri-implantation) endometrial thickness and volume, uterine artery pulsatility index (PI) and resistance index (RI), endometrial and subendometrial vascularization index, flow index, and vascularization flow index, and serum estradiol and progesterone levels were compared between spontaneous and clomiphene citrate stimulated cycles in the same group of 50 patients with unexplained infertility.
Interventions
OTHERVascularization indices observation
The mid-luteal endometrial thickness and volume, uterine vascularization indices of uterine artery pulsatility index and resistance index, endometrial and subendometrial vascularization index, flow index, and vascularization flow index, and serum estradiol and progesterone levels were calculated in spontaneous then stimulated cycles in the same group of infertile patients
Sponsors
Cairo University
Study design
Observational model
CASE_CROSSOVER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
25 Years to 35 Years
Healthy volunteers
No
Inclusion criteria
* Unexplained infertility * Body mass index less than 30 * Regular menstruation * Normal pelvic examination and ultrasonography
Exclusion criteria
* History of pelvic operations including cesarean section * History of pelvic inflammatory disease * Endometriosis * Pelvic pathology including uterine fibroids * General disease or medication that could potentially affect pelvic blood flow * Smoking
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Flow index of the endometrial region | Day 22 to 24 of the menstrual cycle | Flow index of the endometrial region was measured by a researcher |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Vascularization index of the endometrial region | Day 22 to 24 of the menstrual cycle | Vascularization index of the endometrial region was measured by a researcher |
| Vascularization flow index of the endometrial region | Day 22 to 24 of the menstrual cycle | Vascularization flow index of the endometrial region was measured by a researcher |
| Vascularization flow index of the sub-endometrial region | Day 22 to 24 of the menstrual cycle | Vascularization flow index of the sub-endometrial region was measured by a researcher |
| Flow index of the sub-endometrial region | Day 22 to 24 of the menstrual cycle | Flow index of the sub-endometrial region was measured by a researcher |
| Vascularization index of the sub-endometrial region | Day 22 to 24 of the menstrual cycle | Vascularization index of the sub-endometrial region was measured by a researcher |
Countries
Egypt
Outcome results
None listed