Adipokines of Epicardial Adipose Tissue and Atherosclerosis of Coronary Arteries

The Role of Adipokines Secreted by Epicardial Adipose Tissue in the Atherosclerosis of Coronary Arteries

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03322332

Enrollment

160

Registered

2017-10-26

Start date

2017-10-23

Completion date

2018-01-22

Last updated

2017-10-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Adipokines, Coronary Atherosclerosis

Keywords

adiponectin, omentin-1, resistin, RBP4, epicardial fat, Coronary artery disease

Brief summary

The aim of the study is to investigate whether the expression and production of adipokines secreted by the epicardial adipose tissue correlate with the degree of coronary atherosclerosis.

Detailed description

The aim of the study is to investigate whether the expression and production of four adipokines \[adiponectin, omenin-1, resistin and retinol binding protein-4 (RBP4)\] secreted by the epicardial adipose tissue correlate with the degree of coronary atherosclerosis. Specifically, this study aims to investigate whether the expression and production of these adipokines is different between two sites of the heart, that are perfused by coronary arteries with different degrees of stenosis.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

MALE

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

1\) Individuals undergoing cardiac surgery

Exclusion criteria

* Age \< 18 years * HbA1c \> 7.0% * Any change of antidiabetic medication the previous 3 months before the surgery * GFR \< 60 mL/min/1.73 m2 * Liver disease * Cancer * Non-treated hyperthyroidism or hypothyroidism * Autoimmune disease * Infection * Any change in body weight at least 5% the previous 3 months before surgery * Significant dehydration. * Taking any of the following drugs the previous 3 months before surgery: hormones, antiobesity drugs

Design outcomes

Primary

Measure	Time frame	Description
Association between coronary artery disease and epicardial adipokines	Baseline measurement	Comparison of the mRNA and protein production of four adipokines \[adiponectin, omentin-1, resistin, retinol binding protein-4(RBP4)\] from the epicardial adipose tissue between the territories that are supplied by LAD and RCA. This comparison will be performed in the following clusters of groups: 1. Cluster 1: NonDM-0 and DM-0 (comparison between territories that are supplied by non-stenosed coronary arteries) 2. Cluster 2: NonDM-LR and DM-LR (comparison between territories that are supplied by stenosed coronary arteries) 3. Cluster 3: NonDM-L, NonDM-R, DM-L and DM-R (comparison between a territory that is supplied by stenosed coronary artery and another territory that is supplied by non-stenosed coronary artery)

Secondary

Measure	Time frame	Description
Impact of diabetes on epicardial adipokines	Baseline measurement	Comparison of the mRNA and protein production of four adipokines (adiponectin, omentin-1, resistin, RBP4) from the epicardial adipose tissue of the territory that is supplied by LAD or RCA between the following groups: 1. NonDM-0 vs DM-0 2. NonDM-L vs DM-L 3. NonDM-R vs DM-R 4. NonDM-LR vs DM-LR

Countries

Greece

Contacts

Primary ContactEustratios Apostolakis, Professor

stratisapostolakis@yahoo.gr0030 2651099679

Outcome results