Chronic Kidney Diseases, Mesenchymal Stem Cells, Renal Interstitial Fibrosis
Conditions
Keywords
Adipose Tissue-derived Mesenchymal Stem Cells, Chronic Kidney Diseases
Brief summary
To investigate the biological characteristics of adipose tissue-derived mesenchymal stem cells(AMSCs) and its treatment effects on chronic renal failure.
Detailed description
This study aims to investigate the biological characteristics of adipose tissue-derived mesenchymal stem cells(AMSCs) and its effect on oxidative stress, inflammation and mitochondrial damage.We intend to use blood oxygen level-dependent magnetic resonance imaging(BOLD-MRI), emission computed tomography(ECT) and enhanced magnetic resonance imaging to monitor renal oxygenation, tissue perfusion and renal function.Ultimately, we evaluate the treatment effects of AMSCs on chronic renal failure through these observations mentioned above.We hope to delay the progression of renal function in patients with chronic renal failure, and save huge social cost for dialysis by these research.
Interventions
DRUGTreatment group
Adipose tissue-derived mesenchymal stem cells were used to treat patients with chronic renal failure on the basis of conventional treatment.
DRUGControl group
Conventional treatment were used to treat patients with chronic renal failure.
Sponsors
The Affiliated Hospital of Xuzhou Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Enroll the chronic renal failure patients without dialysis in the department of nephrology of Affiliated Hospital of Xuzhou Medical University from January 2017 to December 2018. * The patients enrolled were not treated with drugs that affect the renal blood flow and oxygen consumption, such as ACEI, ARB, calcium channel blockers, diuretics, vasodilators and other related factors within 2 weeks.
Exclusion criteria
* Exclude those patients with diabetes, cardiovascular disease, severe infection, shock, dehydration, abnormal liver function, received glucocorticoid therapy, surgery and emergency dialysis. * Eliminate those patients with respiratory disease(such as chronic obstructive pulmonary disease, bronchiectasis, asthma), cardiovascular diseases(such as acute and chronic cardiac insufficiency), blood system diseases (such as aplastic anemia, nutritional anemia and polycythemia vera).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| serum creatinine | after 3 months of adipose tissue-derived mesenchymal stem cells treatment | intravenous blood sampling |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| glomerular filtration rate | after 3 months of adipose tissue-derived mesenchymal stem cells treatment | emission computed tomography |
| apparent relaxation rate | after 3 months of adipose tissue-derived mesenchymal stem cells treatment | blood oxygen level dependent magnetic resonance imaging |
Countries
China
Contacts
Primary ContactDong Sun, MD
Outcome results
None listed