Value of CA125 and Yolk Sac Morphology in Prediction of Pregnancy Outcome in Threatened Miscarriage

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03320213

Enrollment

192

Registered

2017-10-25

Start date

2016-10-01

Completion date

2017-07-30

Last updated

2017-10-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Threatened Miscarriage in First Trimester

Keywords

CA125, Yolk sac morphology, Threatened miscarriage

Brief summary

evaluation of serum CA125 level and yolk sac morphology in women with threatened miscarriage is very important to predict pregnancy outcome

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

20 Years to 40 Years

Healthy volunteers

Yes

Inclusion criteria

* pregnant women between 20-40 years. Pregnancy between 6-10 weeks. single intrauterine spontaneous pregnancy. vaginal bleeding or bloody vaginal discharge with or without pelvic pain for patients with threatened miscarriage.

Exclusion criteria

* medical disorders with pregnancy. History of recurrent miscarriage. Any maternal disease that would cause an increase in CA125 level. Local gynecological disorders e.g. fibroid. Presence of any uterine malformation. History of congenital abnormalities in previous pregnancy Presence of multiple pregnancy. Presence of anembryonic sac. Absent fetal heart pulsation.

Design outcomes

Primary

Measure	Time frame	Description
Evaluation of serum CA125	6 - 10 weeks	Measuring serum level of CA125 by ELIZA kits.
Evaluation of yolk sac morphology	6 - 10 weeks	Evaluating yolk sac size and shape by transvaginal ultrasound

Secondary

Measure	Time frame	Description
follow up of participants	up to 20 weeks	measuring fetal heart rate by transvaginal ultrasound.

Outcome results