Spondylarthropathy, Sarcopenia
Conditions
Keywords
Spondylarthropathy, Sarcopenia, lean mass, fat mass
Brief summary
Spondylarthropathies (SpA) are among the most common chronic inflammatory rheumatisms in adults, responsible for a muscular loss or sarcopenia which can be very disabling, not much documented in the literature, and not yet studied in France. In addition, sarcopenia is associated with decreased physical activity and increased risk of falls and fractures. A better characterization of the determinants of this muscular loss will allow to better detect and take care of it. The aim is to conduct the first French study on the prevalence and severity of sarcopenia in patients with spondyloarthropathies and to study the variables that may be associated with it. Finally, we propose to evaluate obesity related to sarcopenia in these patients and compare them to cases matched for age and sex (from OFELY / STRAMBO cohorts, Lyon, FRANCE). This is a prospective interventional and monocentric study with minimal risks and constraints: patients will be included for one day for an evaluation of their sarcopenia by measuring their muscle strength, physical performance and body composition and recording of their socio-demographic and disease characteristics.
Interventions
OTHERDynamometry exam
Prehension strength of the main hand will be assessed thanks to dynamometry, in order to evaluate patient's muscular strength
OTHERWalking test
A 4 metres walking test will be performed to assess patient's walking speed
RADIATIONDXA measurement
DXA measurement will be performed to assess patient's body composition
OTHERSARQOL questionnaire
Patient's quality of life will be assessed thanks to the SARQOL questionnaire
BEHAVIORALLife habits Questionnaire
Life habits Questionnaire
Sponsors
Hospices Civils de Lyon
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
SCREENING
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Men and women, 18 to 80 years old * Hospitalized or attending the rheumatology department for spondyloarthopathy.
Exclusion criteria
* no signed consent * Immobilization for a period of more than 15 days during the last 3 months * pregnant or breastfeeding woman * Not affiliated to the national healthcare insurance * difficulty in understanding French * psychiatric disorder
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Muscular strength | At day 1 | Muscular strength is the first outcome to evaluate sarcopenia |
| Walking speed | At day 1 | Walking speed is a physical performance outcome, that is the second outcome to evaluate sarcopenia |
| Muscular mass | Up to 4 month after inclusion | Muscular mass is the third outcome to evaluate sarcopenia and will be assessed using DXA |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Physical activity rate in work | At day 1 | Physical activity rate in work can be light, medium, high or not applicable if the patient does not work ; it is the second outcome to evaluate patient's physical global activity. |
| Alcohol consumption | At day 1 | — |
| Score at the SARQOL questionnaire | At day 1 | Quality of life will be assessed thanks to the SARQOL questionnaire (score between 0 and 100) |
| Average walking time in a week | At day 1 | Average walking time in a week is the third outcome to evaluate patient's physical global activity. |
| Tobacco consumption | At day 1 | — |
| Time of sport practice per month | At day 1 | Number of hours of sport practice per month is the first outcome to evaluate patient's global physical activity. |
Countries
France
Outcome results
None listed