Cardiopulmonary Disease
Conditions
Brief summary
The objective of this study is to investigate the cardiopulmonary health effects of indoor air purification and different indoor environmental factors among school students in Beijing.
Detailed description
This randomized, double-blind crossover study was conducted to explore the cardiopulmonary effects of ionization air purification among 48 children in Beijing. Real or sham purification was performed in classrooms for 5 weekdays in a random order with a 2-month wash-out period. During the study periods, different indoor environmental factors were monitored including size-fractionated particulate matter (PM), black carbon (BC), ozone, carbon dioxide (CO2), negative air ions (NAI), noise, temperature and relative humidity, which were controlled as confounders in the analysis of the effects of indoor air purification. In addition, we analyzed the cardiopulmonary effects of those environmental factors on the children.
Interventions
OTHERAir purifier
active- or sham-mode air purifier used in 6 classrooms in a school with a crossover design
Sponsors
Peking University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
10 Years to 14 Years
Healthy volunteers
Yes
Inclusion criteria
* living in Beijing for more than two consecutive years; * living in school dormitories from Monday to Friday.
Exclusion criteria
* suffering any health condition; * having asthma or thoracic surgery history.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Levels of lung function indicators | 10 weekdays for intervention (active or sham) and 2 wash-out months | Lung function test was conducted including forced expiratory volume in one second (FEV1) and peak expiratory flow (PEF). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Changes in autonomic cardiac function | 10 weekdays for intervention (active or sham) and 2 wash-out months | Ambulatory electrocardiogram (ECG) was monitored including heart rate (HR) and heart rate variability (HRV). |
| Level of respiratory inflammation | 10 weekdays for intervention (active or sham) and 2 wash-out months | Fractional exhaled nitric oxide (FeNO) test was conducted. |
| Changes in ST-segment elevation | 10 weekdays for intervention (active or sham) and 2 wash-out months | Ambulatory electrocardiogram (ECG) was monitored. |
| Levels of oxidative stress in Exhaled Breath Condensate (EBC) | 10 weekdays for intervention (active or sham) and 2 wash-out months | EBC was collected using a designated device for oxidative stress analysis. |
| Levels of urinary metabolomics | 10 weekdays for intervention (active or sham) and 2 wash-out months | Urine samples were collected for metabolomics analysis. |
Countries
China
Outcome results
None listed