Effect of Granisetron on Usage of Sympathomimetics During Caesarean Section

Effect of Granisetron on Usage of Sympathomimetics During Caesarean Section - a Retrospective Analysis

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03318536

Enrollment

240

Registered

2017-10-24

Start date

2017-10-05

Completion date

2018-02-01

Last updated

2018-05-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypotension, Cesarean Section Complications

Keywords

Serotonin Antagonists, Sympathomimetics

Brief summary

The aim of the present study is to quantify the dose and usage of sympathomimetics used in caesarean section.

Detailed description

Recent metaanalysis showed significantly reduced hypotension and bradycardia in patients undergoing caesarean section in spinal anesthesia when 5-hydroxytryptamine 3 receptor antagonists were used prophylactically. Due to this fact in our clinic the standard procedure was changed. All patients for caesarean section receive Granisetron before spinal anesthesia. The aim of the present study is to evaluate the usage and dose of sympathomimetics during spinal anesthesia. Therefore the investigators will evaluate approximately 120 participants who received granisetron and 120 participants who did not receive 5-hydroxytryptamine 3 receptor antagonists.

Interventions

DRUGGranisetron Hydrochloride

Patients received Granisetron.

DRUGNo Granisetron

Patients who did not receive Granisetron.

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Healthy volunteers

Yes

Inclusion criteria

* caesarean section in spinal anesthesia

Exclusion criteria

* withdrawal * incomplete documentation

Design outcomes

Primary

Measure	Time frame	Description
Sympathomimetics	30 minutes starting with induction of spinal anesthesia.	Type of sympathomimetics during during the operation

Secondary

Measure	Time frame	Description
Volume substitution	30 minutes starting with induction of spinal anesthesia.	Type of perioperative infused volume during the operation
Haemotherapy	30 minutes starting with induction of spinal anesthesia.	Type of haemotherapy.
Sympathomimetics	30 minutes starting with induction of spinal anesthesia.	Cumulative dose of sympathomimetics during during the operation
Oxytocin	30 minutes starting with induction of spinal anesthesia.	Duration until first administration of oxytocin.
Uterotonic agents	30 minutes starting with induction of spinal anesthesia.	Kind of uterotonic agents.
Duration until first application of sympathomimetics	30 minutes starting with induction of spinal anesthesia.	Duration until first administration of any kind of sympathomimetics.

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 21, 2026