Amphetamine Addiction
Conditions
Keywords
Amphetamine-type stimulants, prefrontal-striatal circuits, cognitive rehabilitation therapy
Brief summary
The computerized cognitive rehabilitation therapy will be used to treat amphetamine-type stimulant (ATS) addiction.
Detailed description
The deficits in executive functions related to prefrontal-striatal circuits play a vital role in ATS addiction and relapse, and proposed computerized cognitive rehabilitation therapy as the novel interventions. Focused on evaluating and training executive functions including working memory, inhibitory control, cognitive flexibility, and congitive bias concerning prefrontal-striatal circuits, neuropsychological tests, electroencephalography tests, magnetic resonance spectroscopy (MRS) and functional MRI will be used to evaluate the therapeutic effect of ATS addiction treatment as well as investigate the mechanisms. The study will be very helpful to develop novel interventions in clinical practice and decrease ATS-related harm for both the patients and their families.
Interventions
BEHAVIORALcognitive function rehabilitation and bias modification
cognitive rehabilitation focus on the deficits executive funcitin and elevated cognitive bias
Sponsors
Shanghai Mental Health Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
1. diagnosed MA dependence in accordance with the fourth edition of the American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) (Association, 2000); 2. more than 9 years of education; 3. aged of 18-60 years old; 4. normal vision, audition and no color blindness; 5. receive no detoxification medications during treatment and 6. right handedness.
Exclusion criteria
1. current medical diseases that required hospitalization or regular monitoring; 2. serious physical or neurological illness that required pharmacological treatment affecting cognitive function; 3. history of major psychiatric disorder such as bipolar disorder, schizophrenia, depression and disorders of high comorbidity with substance abuse/dependence; 4. neurological diseases such as stroke, seizure, migraine, head trauma 5. substance dependence other than nicotine, within the past 5 years; 6. intelligence quotient (IQ) \<70.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change from Baseline Craving for ATS assessed by Visual Analog Scales (VAS) at 1 month , 3 month and 6 months | Baseline, 1 month, 3 month and 6 months | evaluate all participants' craving for ATS by Visual Analog Scales (VAS): The scores of the VAS were 0-10 points. 10 points reflect the highest level of individual's craving, and 0 point reflect no craving in patient. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Cognitive function assessed by CogState Battery (CSB) | Baseline, 1 month, 3 month and 6 months | evaluate all participants' cognitive function by the computerized CogState Battery (CSB) Chinese version: The five tasks listed below were examined. International shopping list task (ISLT, verbal learning and memory), the score is defined as the total number of correct responses. Continuous paired association learning task (CPAL) taps spatial working memory. Groton maze learning task (GML) taps problem solving/error monitoring. The scores of CPAL and GML tasks are the total number of errors. Social emotional cognition task (SEC, social cognition) asks the subjects to pick out the different facial expressions. Two back task (TWOB, working memory) requires subjects to decide whether a card is identical to the one shown just before. The scores of TWOB and SEC tasks are the proportion of correct responses, denoting the accuracy of performance. The higher values represent a better outcome in ISL, SEC and TWOB. The higher values represent a worse outcome in GML and CPAL. |
| Changing of response inhibition ablility assessed by Balloon Analogue Risk Task (BART) | Baseline, 1 month, 3 month and 6 months | evaluate all participants' response inhibition function by Balloon Analogue Risk Task (BART): Several indices were computed to represent the behavioral performance, including the ratio of all pumps to numbers of win trials, the ratio of pumps to numbers in win trials, and the number of win trials. The higher values represent a worse outcome. |
| Number of participants who relapse | 1 month, 3 month and 6 months | Follow up with patients after discharge, evaluate number of participants who relapse. The higher values represent a worse outcome. |
Countries
China
Outcome results
None listed