Genotype, Metabotype and Diet in a Cohort of Children and Adolescents From the Southeast of Spain.

Association Between Genotype, Polyphenol Gut Microbiota Metabotypes, and Diet in a Cohort of Children and Adolescents From the Southeast of Spain.

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03318042

Acronym

PolyMicroBio

Enrollment

423

Registered

2017-10-23

Start date

2016-02-01

Completion date

2016-11-02

Last updated

2017-10-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Genotype, Metabotype and Dietary Habits

Brief summary

The objective of this study is to investigate the possible association between 60 SNPs related to obesity, metabolism and cardiovascular disease with BMI, intestinal microbiota and adherence to the Mediterranean diet in a cohort of children and adolescents from the southeast of Spain.

Detailed description

The objective of this study is to investigate the possible association between 60 single nucleotide polymorphisms (SNPs) related to obesity, metabolism and cardiovascular disease with the body mass index (BMI), intestinal microbiota related to the metabolism of polyphehnos and adherence to the Mediterranean diet in a cohort of children and adolescents from the southeast of Spain. The volunteers (n=423) with ages ranging from 5 to 18 years consumed for three days a daily serving of walnuts (30g) and provided a sample of urine (to determine mirobial-derived metabolites from walnut polyphenols) as well as a swab specimen from the inner cheek to provide DNA for further genotyping.

Interventions

OTHERWalnuts

The group consumed a daily serving of walnuts (30 g) or 200 mL pomegranate juice for 3 days and provided a sample of urine as well as a swab specimen from the inner cheek

OTHERPomegranate juice

Those volunteers who were allergic to nuts consumed 200 mL pomegranate juice daily for 3 days and provided a sample of urine as well as a swab specimen from the inner cheek

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

SCREENING

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

5 Years to 18 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy individuals aged 5 to 18 years. * Informed consent signed by the parent / legal representative, and by volunteers who are already 18 years old.

Exclusion criteria

* Known or suspected allergy or intolerance to nuts or pomegranate. * Intake of antibiotics 1 month before the start of the study. * If the participant could perceive stress or psychological damage due to his participation. * Any other circumstance different from previous ones (illness, etc.), according to which it is considered that the intervention in the study may involve some type of affectation.

Design outcomes

Primary

Measure	Time frame	Description
Polyphenol metabotypes	1 to 3 months	Type of ellagic acid-derived microbial metabolites in urine

Secondary

Measure	Time frame	Description
Genotype	1 to 6 months	Detection of 60 SNPs related to obesity, metabolism and cardiovascular disease
Adherence to Mediterranean diet	1 to 3 months	Evaluation of the adherence to Mediterranean diet using validated questionnaires

Countries

Spain

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026