A Comparison of Clinical Outcomes of Warmed Embryo Vitrified at 2PN Stage and Fresh Embryo Transfers

Infertility, Female, Reproductive Disorder

The aim of this study was to compare the clinical outcomes between fresh embryo and frozen embryo transfer in in vitro fertilization (IVF). All frozen embryo was vitrified at pronuclear stage (2PN) and cultured to cleavage embryos for transfer. This is a retrospective study. All IVF cycles were included in this study and further divided into fresh and frozen embryo transfer groups. The collection data including: stimulation protocols, medicines, blood test results, pregnancy test and all clinical data. The primary outcome is pregnancy rate and secondary outcome is implantation rate.

Study design Study progress: Stage 1: collection of all data from frozen embryo transfer and fresh embryo transfer groups. Stage 2: selection data and check the delivery outcomes Stage 3: analysis data and presentation. Including criteria: all patients who underwent IVF. Excluding criteria: No. Statistics analysis: chi-test, t-test Assessment point: Primary endpoint: pregnancy rate Secondary endpoint: implantation rate Withdraw criteria: not application. Treatments: not application. Collection number: 500 patients. Scheduled trial period: 2017.05.01\ 2018.04.30 Expected research results: The implantation rate in frozen embryo transfer group which vitrified at 2PN stage is higher than fresh embryo transfer. The pregnancy rate in frozen embryo transfer group which vitrified at 2PN stage is higher than fresh embryo transfer. This study is only data analysis, no additional collection of samples. This study does not involve vulnerable groups.

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