Posterior Circulation Brain Infarction
Conditions
Keywords
Anesthesia Methods, Acute Ischemic Stroke, Endovascular Treatment
Brief summary
There is few randomized controlled clinical to investigated the impact of anesthetic type on outcome in patients with acute ischemic stroke in posterior cerebral circulation. It is unknown whether the choice of anesthesia is impacted on the outcomes for these patients or not. The investigators will perform a randomized controlled pilot clinical trial of general anesthesia versus local anesthesia/conscious sedation to explore and find out a potential fact whether anesthetic type alters perioperative neurological function in patients with acute ischemic stroke in posterior cerebral circulation.
Interventions
PROCEDUREGeneral anesthesia
Patients will be injected with propofol, remifentanil and muscular relaxant with controlled ventilation.
PROCEDURELocal anesthesia/concious sedation
Patients will be injected with propofol and remifentanil.
PROCEDURESpontaneous breath
Patients will be kept spontaneous breath.
PROCEDUREControlled ventilation
Patient will be kept with controlled ventilation.
Sponsors
Beijing Tiantan Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* Patients with acute ischemic stroke in posterior cerebral circulation scheduled to receive emergency endovascular treatment; Age \> 18; The onset time is within 24 hours; Modified rankin score ≤2 before onset.
Exclusion criteria
* Radiological ambiguity concerning infarction and vessel occlusion; Additional intracerebral hemorrhage; Anterior circulation infraction; Coma on admission (Glasgow coma score less than 8); NIHSS less than 6 or more than 30; Severe agitation or seizures on admission; Obvious loss of airway protective reflexes and/or vomiting on admission; Being intubated before treatment on admission; Known allergy to anesthetic or analgesic;
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| modified rankin score（mRS） | post-procedural 90 days | Modified rankin score（mRS）is used to evaluate the primary outcome. The scale of mRS is 0 to 6. The best neurological outcome is the mRS with 0, indicating no any symptom left, and a good neurological outcome is agreed with a mRS≤2. mRS of 6 is the worst, indicating death. mRS will be evaluated by outcomes assessor who is blinded to the grouping. |
Countries
China
Outcome results
None listed